Aciculin Antibody (14F8): sc-73613
- Aciculin Antibody (14F8) is a mouse monoclonal IgG1 κ Aciculin antibody, cited in 2 publications, provided at 200 µg/ml
- raised against Aciculin of human origin
- Aciculin Antibody (14F8) is recommended for detection of aciculin of mouse, rat, human, bovine and avian origin by WB, IP, IF and IHC(P); non cross-reactive with phosphoglucomutase
- Anti-Aciculin Antibody (14F8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Aciculin Antibody (14F8) for WB and IHC(P) applications. These reagents are now offered in bundles with Aciculin Antibody (14F8) (see ordering information below).
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Aciculin Antibody (14F8) is a mouse monoclonal IgG1 kappa light chain antibody that detects Aciculin protein of mouse, rat, human, bovine, and avian origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Aciculin antibody (14F8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Aciculin, also known as PGM5 (phosphoglucomutase 5) or PGMRP, is a 567 amino acid protein that plays a crucial role in the interconversion of glucose-1-phosphate and glucose-6-phosphate, which is vital for cellular energy metabolism and glycogen synthesis. Aciculin is localized at cell junctions and is predominantly expressed in smooth and cardiac muscle, where Aciculin binds magnesium as a cofactor, facilitating enzymatic activity. Aciculin interacts with key structural proteins such as dystrophin and utrophin, suggesting involvement in maintaining cytoskeletal integrity and function. Notably, Aciculin exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 9, a region that contains over 900 genes and represents nearly 4% of the human genome, highlighting potential significance in various biological processes and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Aciculin Antibody (14F8) References:
- Aciculin and its relation to dystrophin: immunocytochemical studies in human normal and Duchenne dystrophy quadriceps muscles. | Wakayama, Y., et al. 2000. Acta Neuropathol. 99: 654-62. PMID: 10867799
- Localization of utrophin and aciculin at sites of cell-matrix and cell-cell adhesion in cultured cells. | Belkin, AM. and Burridge, K. 1995. Exp Cell Res. 221: 132-40. PMID: 7589238
- Association of aciculin with dystrophin and utrophin. | Belkin, AM. and Burridge, K. 1995. J Biol Chem. 270: 6328-37. PMID: 7890770
- Expression and localization of the phosphoglucomutase-related cytoskeletal protein, aciculin, in skeletal muscle. | Belkin, AM. and Burridge, K. 1994. J Cell Sci. 107 (Pt 7): 1993-2003. PMID: 7983164
- A novel dystrophin/utrophin-associated protein is an enzymatically inactive member of the phosphoglucomutase superfamily. | Moiseeva, EP., et al. 1996. Eur J Biochem. 235: 103-13. PMID: 8631316
- Dystrophin, vinculin, and aciculin in skeletal muscle subject to chronic use and disuse. | Rezvani, M., et al. 1996. Med Sci Sports Exerc. 28: 79-84. PMID: 8775358
- Localization of cranin (dystroglycan) at sites of cell-matrix and cell-cell contact: recruitment to focal adhesions is dependent upon extracellular ligands. | Belkin, AM. and Smalheiser, NR. 1996. Cell Adhes Commun. 4: 281-96. PMID: 9117347
- Characterisation of the promoter which regulates expression of a phosphoglucomutase-related protein, a component of the dystrophin/utrophin cytoskeleton predominantly expressed in smooth muscle. | Moiseeva, EP. and Critchley, DR. 1997. Eur J Biochem. 248: 634-43. PMID: 9342213
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aciculin Antibody (14F8) | sc-73613 | 200 µg/ml | $322.00 | |||
Aciculin Antibody (14F8): m-IgG Fc BP-HRP Bundle | sc-528656 | 200 µg Ab; 10 µg BP | $361.00 | |||
Aciculin Antibody (14F8): m-IgGκ BP-HRP Bundle | sc-521101 | 200 µg Ab, 40 µg BP | $361.00 | |||
Aciculin Antibody (14F8) AC | sc-73613 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Aciculin Antibody (14F8) HRP | sc-73613 HRP | 200 µg/ml | $322.00 | |||
Aciculin Antibody (14F8) FITC | sc-73613 FITC | 200 µg/ml | $336.00 | |||
Aciculin Antibody (14F8) PE | sc-73613 PE | 200 µg/ml | $349.00 | |||
Aciculin Antibody (14F8) Alexa Fluor® 488 | sc-73613 AF488 | 200 µg/ml | $364.00 | |||
Aciculin Antibody (14F8) Alexa Fluor® 546 | sc-73613 AF546 | 200 µg/ml | $364.00 | |||
Aciculin Antibody (14F8) Alexa Fluor® 594 | sc-73613 AF594 | 200 µg/ml | $364.00 | |||
Aciculin Antibody (14F8) Alexa Fluor® 647 | sc-73613 AF647 | 200 µg/ml | $364.00 | |||
Aciculin Antibody (14F8) Alexa Fluor® 680 | sc-73613 AF680 | 200 µg/ml | $364.00 | |||
Aciculin Antibody (14F8) Alexa Fluor® 790 | sc-73613 AF790 | 200 µg/ml | $364.00 |