Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 Antibody (G-4): sc-376966
- Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 Antibody (G-4) is a mouse monoclonal IgG1 κ Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 399-437 within a cytoplasmic domain of AChRα6 of human origin
- Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 Antibody (G-4) is recommended for detection of AChRα6 of human origin by WB, IP, IF and ELISA
- Anti-Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 Antibody (G-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 Antibody (G-4). This work is in progress.
AChRα6 Antibody (G-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects AChRα6 by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-AChRα6 antibody (G-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AChRα6, also known as cholinergic nicotinic receptor α polypeptide 6, plays a crucial role in the central nervous system and is primarily located in the respiratory mucosa and dopaminergic terminals. AChRα6 presence at the postsynaptic membrane of the neuromuscular junction is vital for the transmission of signals between nerve cells and muscles, as AChRα6 binds acetylcholine and facilitates the movement of ions through its transmembrane pore. This ion flow is essential for muscle contraction and neurotransmission, highlighting AChRα6 importance in both motor function and cognitive processes. AChRα6 forms complexes with AChRβ2 and AChRα4, which are critical for the receptor′s functionality and modulation, making AChRα6 a significant target for research in neurobiology and pharmacology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 Antibody (G-4) References:
- Behavioral neuroendocrinology: chemical correlates. | Robins, E. 1975. Psychopharmacol Bull. 11: 56-7. PMID: 1135380
- Identification of the nicotinic receptor subtypes expressed on dopaminergic terminals in the rat striatum. | Zoli, M., et al. 2002. J Neurosci. 22: 8785-9. PMID: 12388584
- Upregulation of [3H]methyllycaconitine binding sites following continuous infusion of nicotine, without changes of alpha7 or alpha6 subunit mRNA: an autoradiography and in situ hybridization study in rat brain. | Mugnaini, M., et al. 2002. Eur J Neurosci. 16: 1633-46. PMID: 12431215
- Nicotinic cholinergic receptor expression in the human nasal mucosa. | Keiger, CJ., et al. 2003. Ann Otol Rhinol Laryngol. 112: 77-84. PMID: 12537063
- Developmental expression of heteromeric nicotinic receptor subtypes in chick retina. | Vailati, S., et al. 2003. Mol Pharmacol. 63: 1329-37. PMID: 12761343
- Incomplete incorporation of tandem subunits in recombinant neuronal nicotinic receptors. | Groot-Kormelink, PJ., et al. 2004. J Gen Physiol. 123: 697-708. PMID: 15148328
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 Antibody (G-4) | sc-376966 | 200 µg/ml | $316.00 | |||
Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 Antibody (G-4) AC | sc-376966 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 Antibody (G-4) HRP | sc-376966 HRP | 200 µg/ml | $316.00 | |||
Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 Antibody (G-4) FITC | sc-376966 FITC | 200 µg/ml | $330.00 | |||
Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 Antibody (G-4) PE | sc-376966 PE | 200 µg/ml | $343.00 | |||
Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 Antibody (G-4) Alexa Fluor® 488 | sc-376966 AF488 | 200 µg/ml | $357.00 | |||
Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 Antibody (G-4) Alexa Fluor® 546 | sc-376966 AF546 | 200 µg/ml | $357.00 | |||
Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 Antibody (G-4) Alexa Fluor® 594 | sc-376966 AF594 | 200 µg/ml | $357.00 | |||
Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 Antibody (G-4) Alexa Fluor® 647 | sc-376966 AF647 | 200 µg/ml | $357.00 | |||
Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 Antibody (G-4) Alexa Fluor® 680 | sc-376966 AF680 | 200 µg/ml | $357.00 | |||
Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 Antibody (G-4) Alexa Fluor® 790 | sc-376966 AF790 | 200 µg/ml | $357.00 | |||
Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 (G-4) Neutralizing Peptide | sc-376966 P | 100 µg/0.5 ml | $68.00 |