ACE Antibody (5C5): sc-23909

ACE Antibody (5C5) is a mouse monoclonal IgG1 kappa light chain antibody designed to target angiotensin-converting enzyme (ACE), also known as CD143 or Angiotensin Converting Enzyme 1. ACE monoclonal antibody (5C5) is raised against human lung-derived ACE and effectively detects ACE proteins from mouse, rat, and human origins through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-ACE antibody (5C5) is available in both non-conjugated and various conjugated forms, including horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and different Alexa Fluor® variants, providing flexibility for diverse research needs. Angiotensin-converting enzyme (ACE) is a membrane-bound carboxy-terminal dipeptidyl exo-peptidase located on the surface of vascular endothelial cells in organs such as the lung, liver, adrenal cortex, pancreas, kidney, and spleen. ACE plays a pivotal role in the renin-angiotensin system by converting Angiotensin I into the potent vasopressor hormone Angiotensin II, thereby regulating blood pressure and electrolyte balance. Additionally, ACE inactivates bradykinin, a vasodepressor peptide, contributing to fluid and electrolyte homeostasis. There are two primary isoforms of ACE: pulmonary ACE (ACEP) and testicular ACE (ACET), with ACEP being widely expressed in the vasculature and ACET exclusively in adult testis by developing sperm cells. The precise cellular localization of ACE is critical for its function in cardiovascular health and disease, making ACE monoclonal antibody (5C5) an essential tool for researchers investigating hypertension, cardiovascular disorders, and related physiological processes.

The preferred ACE antibody is ACE Antibody (2E2): sc-23908.