ACAD-11 Antibody (B-12): sc-514027

ACAD-11 Antibody (B-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects ACAD-11 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ACAD-11 (B-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ACAD-11, also known as acyl-Coenzyme A dehydrogenase family member 11, plays a crucial role in fatty acid and amino acid metabolism, serving as a vital energy source for heart and skeletal muscle tissues. This 780 amino acid protein is expressed in three alternatively spliced isoforms and is encoded by a gene located on chromosome 3, which is significant not only for its role in energy metabolism but also for its association with various genetic diseases, including Marfan Syndrome and von Hippel-Lindau syndrome. ACAD-11′s structure, characterized by unique folding and active site configuration, is essential for enzymatic function, allowing catalysis of acyl-CoA substrate dehydrogenation. Understanding ACAD-11′s structure is important for elucidating its role in metabolic pathways and potential implications in metabolic disorders.

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ACAD-11 Antibody (B-12) References:

1. Molecular cytogenetic dissection of human chromosomes 3 and 21 evolution.  |  Müller, S., et al. 2000. Proc Natl Acad Sci U S A. 97: 206-11. PMID: 10618396
2. [New tumor suppressor genes in hot spots of human chromosome 3: new methods of identification].  |  Braga, EA., et al. 2003. Mol Biol (Mosk). 37: 194-211. PMID: 12723467
3. Plasticity of human chromosome 3 during primate evolution.  |  Tsend-Ayush, E., et al. 2004. Genomics. 83: 193-202. PMID: 14706448
4. Genomic structure and paralogous regions of the inversion breakpoint occurring between human chromosome 3p12.3 and orangutan chromosome 2.  |  Yue, Y., et al. 2005. Cytogenet Genome Res. 108: 98-105. PMID: 15545721
5. Comparative cytogenetics of human chromosome 3q21.3 reveals a hot spot for ectopic recombination in hominoid evolution.  |  Yue, Y., et al. 2005. Genomics. 85: 36-47. PMID: 15607420
6. Evolutionarily plastic regions at human 3p21.3 coincide with tumor breakpoints identified by the 'elimination test'.  |  Darai, E., et al. 2005. Genomics. 86: 1-12. PMID: 15913951
7. The DNA sequence, annotation and analysis of human chromosome 3.  |  Muzny, DM., et al. 2006. Nature. 440: 1194-8. PMID: 16641997
8. Establishment and characterization of two uveal melanoma cell lines derived from tumors with loss of one chromosome 3.  |  Nareyeck, G., et al. 2006. Exp Eye Res. 83: 858-64. PMID: 16750193
9. Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function.  |  Jiang, D., et al. 2015. Cell Rep. 10: 1096-109. PMID: 25704813
10. ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism.  |  Rashan, EH., et al. 2024. bioRxiv.. PMID: 38260250
11. ACAD10 and ACAD11 allow entry of 4-hydroxy fatty acids into β-oxidation.  |  Paquay, S., et al. 2024. Cell Mol Life Sci. 81: 367. PMID: 39174697
12. The regulation of acyl-CoA dehydrogenases in adipose tissue by rosiglitazone.  |  Goetzman, ES. 2009. Obesity (Silver Spring). 17: 196-8. PMID: 18948967

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ACAD-11 Antibody (B-12) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-ACAD-11 Antibody (B-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ACAD-11 Antibody (B-12) Specifications

Alternate Product Name: ACAD-11

Product Clone Name: B-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 120-140

Epitope Target: ACAD-11

Epitope Species: human

Product Reactivity/Detection: ACAD-11

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for ACAD-11 Antibody (B-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin