ABCG2 Antibody (B-1): sc-377176
- ABCG2 Antibody (B-1) is a mouse monoclonal IgG1 κ ABCG2 antibody, cited in 46 publications, provided at 200 µg/ml
- raised against amino acids 301-370 mapping within an internal region of ABCG2 of human origin
- ABCG2 Antibody (B-1) is recommended for detection of ABCG2 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-ABCG2 Antibody (B-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for ABCG2 Antibody (B-1) for WB and IHC(P) applications. This reagent is now offered in a bundle with ABCG2 Antibody (B-1) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
ABCG2 Antibody (B-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects ABCG2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-ABCG2 antibody (B-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ABCG2, also known as placenta-specific ABC transporter and breast cancer resistance protein (BCRP1), plays a crucial role in transporting various substrates across cellular membranes using energy from ATP hydrolysis. ABCG2 confers resistance to several chemotherapeutic agents, including anthracyclines and topotecan, impacting treatment efficacy in cancer patients. ABCG2 is predominantly expressed in placenta, liver, intestine, and various stem cells, where ABCG2 regulates stem cell differentiation and maintains side population (SP) phenotype, indicating stem cell properties. ABCG2 undergoes post-translational modifications such as N-linked glycosylation, influencing stability and function, and dimerizes in vivo, highlighting a complex role in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ABCG2 Antibody (B-1) References:
- ABCB1 and ABCG2 expression in the placenta and fetus: an interspecies comparison. | Myllynen, P., et al. 2010. Expert Opin Drug Metab Toxicol. 6: 1385-98. PMID: 20738225
- The role of ABCG2 and ABCB6 in porphyrin metabolism and cell survival. | Krishnamurthy, P. and Schuetz, JD. 2011. Curr Pharm Biotechnol. 12: 647-55. PMID: 21118089
- Metabolism of KO143, an ABCG2 inhibitor. | Liu, K., et al. 2017. Drug Metab Pharmacokinet. 32: 193-200. PMID: 28619281
- Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response. | Brackman, DJ. and Giacomini, KM. 2018. Clin Pharmacol Ther. 103: 233-242. PMID: 29023674
- Abcg2 transporter affects plasma, milk and tissue levels of meloxicam. | Garcia-Lino, AM., et al. 2020. Biochem Pharmacol. 175: 113924. PMID: 32217099
- Overexpression of ABCG2 Confers Resistance to MLN7243, a Ubiquitin-Activating Enzyme (UAE) Inhibitor. | Wu, ZX., et al. 2021. Front Cell Dev Biol. 9: 697927. PMID: 34336849
- Impact of ABCG2 Gene Polymorphism on the Predisposition to Psoriasis. | Huang, YH., et al. 2021. Genes (Basel). 12: PMID: 34680995
- Nucleotide binding is the critical regulator of ABCG2 conformational transitions. | Gyöngy, Z., et al. 2023. Elife. 12: PMID: 36763413
- ABCG2 Gene and ABCG2 Protein Expression in Colorectal Cancer-In Silico and Wet Analysis. | Sałagacka-Kubiak, A., et al. 2023. Int J Mol Sci. 24: PMID: 37445716
- ABCG2 Expression as a Potential Survival Predictor in Human Gliomas. | Raguž, M., et al. 2024. Int J Mol Sci. 25: PMID: 38542090
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ABCG2 Antibody (B-1) | sc-377176 | 200 µg/ml | $322.00 | |||
ABCG2 Antibody (B-1): m-IgGκ BP-HRP Bundle | sc-523225 | 200 µg Ab, 40 µg BP | $361.00 | |||
ABCG2 Antibody (B-1) AC | sc-377176 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ABCG2 Antibody (B-1) HRP | sc-377176 HRP | 200 µg/ml | $322.00 | |||
ABCG2 Antibody (B-1) FITC | sc-377176 FITC | 200 µg/ml | $336.00 | |||
ABCG2 Antibody (B-1) PE | sc-377176 PE | 200 µg/ml | $349.00 | |||
ABCG2 Antibody (B-1) Alexa Fluor® 488 | sc-377176 AF488 | 200 µg/ml | $364.00 | |||
ABCG2 Antibody (B-1) Alexa Fluor® 546 | sc-377176 AF546 | 200 µg/ml | $364.00 | |||
ABCG2 Antibody (B-1) Alexa Fluor® 594 | sc-377176 AF594 | 200 µg/ml | $364.00 | |||
ABCG2 Antibody (B-1) Alexa Fluor® 647 | sc-377176 AF647 | 200 µg/ml | $364.00 | |||
ABCG2 Antibody (B-1) Alexa Fluor® 680 | sc-377176 AF680 | 200 µg/ml | $364.00 | |||
ABCG2 Antibody (B-1) Alexa Fluor® 790 | sc-377176 AF790 | 200 µg/ml | $364.00 |