ABCG2 Antibody (BXP-53): sc-58224

ABCG2 Antibody (BXP-53) is a rat monoclonal IgG2a antibody that detects ABCG2 in mouse, rat, and human samples by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-ABCG2 antibody (BXP-53) is available in a non-conjugated form, providing researchers with a versatile tool for studying this critical protein. ABCG2, also known as the placenta-specific ABC transporter and breast cancer resistance protein (BCRP1), plays a vital role in the transport of various molecules across cellular membranes, utilizing energy derived from ATP hydrolysis. ABCG2 is particularly significant due to involvement in conferring resistance to a range of chemotherapeutic agents, including anthracyclines and topotecan, which poses challenges in cancer treatment. ABCG2 is crucial for maintaining the side population (SP) phenotype in stem cells, highlighting importance as a stem cell marker. ABCG2 is predominantly expressed in the placenta, liver, intestine, and various stem cells, where ABCG2 may serve a protective function by expelling toxins from the cell and regulating stem cell differentiation. Notably, ABCG2 may undergo N-linked glycosylation and has the potential to dimerize in vivo, which can influence functional properties and interactions with other proteins. This multifaceted role of ABCG2 underscores significance in both normal physiology and disease states, making ABCG2 (BXP-53) antibody an essential reagent for researchers investigating diverse functions and implications in therapeutic resistance.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ABCG2 Antibody (BXP-53) has 24 citations in a variety of scientific publications.

Primary antibodies like Anti-ABCG2 Antibody (BXP-53) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ABCG2 Antibody (BXP-53) Specifications

Alternate Product Name: CD338

Product Clone Name: BXP-53

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids: 221-394

Epitope Target: ABCG2

Epitope Species: mouse

Product Reactivity/Detection: ABCG2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% stabilizer protein

Research Citations: 24 citations in various scientific publications

Available Conjugates/Forms for ABCG2 Antibody (BXP-53): N/A