AASS Antibody (G-7): sc-390536

AASS Antibody (G-7) is a mouse monoclonal IgG1 antibody that detects alpha-aminoadipic semialdehyde synthase (AASS) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). AASS is a crucial bifunctional enzyme located in the mitochondria, where AASS exists as a homodimer and plays a vital role in lysine degradation by catalyzing the first two steps of this metabolic pathway. AASS exhibits lysine alpha-ketoglutarate reductase and saccharopine dehydrogenase activities, which are essential for maintaining amino acid homeostasis and preventing the accumulation of toxic metabolites. Notably, AASS gene expression is significantly induced during starvation, highlighting AASS importance in metabolic adaptation. Mutations in the AASS gene can lead to familial hyperlysinemias, a group of autosomal recessive disorders characterized by elevated lysine levels, yet patients typically do not experience adverse mental or physical effects. Anti-AASS antibody (G-7) serves as an invaluable tool for researchers studying lysine metabolism and its associated disorders, providing insights into AASS function and implications in metabolic health.

The preferred AASS antibody is AASS Antibody (H-5): sc-390511.