A20/TNFAIP3 Antibody (B-5): sc-376564
- A20/TNFAIP3 Antibody (B-5) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 491-523 within an internal region of A20 of human origin
- recommended for detection of A20 of human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-376564 X, 200 µg/0.1 ml)
- See A20/TNFAIP3 (A-12): sc-166692 for A20/TNFAIP3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for A20/TNFAIP3 Antibody (B-5) for WB applications. These reagents are now offered in bundles with A20/TNFAIP3 Antibody (B-5) (see ordering information below).
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SEE ALSO...
A20 Antibody (B-5) is a mouse monoclonal IgG1 antibody that detects A20 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). A20 is a Cys2/Cys2 zinc finger protein that plays a pivotal role in regulating inflammatory responses by acting as a negative regulator of nuclear factor κ B (NFκB) gene expression. This regulation is crucial because NFκB is a key transcription factor involved in the immune response, and uncontrolled activation can lead to chronic inflammation and various diseases. A20 is induced by inflammatory stimuli such as tumor necrosis factor (TNF) and interleukin 1 (IL-1), effectively terminating NFκB responses by inhibiting activation. A20′s structure includes seven zinc finger domains, with four being essential for in vitro inhibition of TNF-induced NFκB activation. A20 interacts with several proteins, including TRAF2, TRAF6, and IκB kinase (IKK) γ, which further enhances ability to prevent cell death. TXBP151, a novel A20-binding protein, may play a role in mediating A20′s anti-apoptotic activity. Given involvement in the negative feedback regulation of signal transduction, A20 and binding partners present promising avenues for therapeutic intervention in a range of inflammatory diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A20/TNFAIP3 Antibody (B-5) | sc-376564 | 200 µg/ml | $322.00 | |||
A20/TNFAIP3 Antibody (B-5): m-IgG Fc BP-HRP Bundle | sc-540599 | 200 µg Ab; 10 µg BP | $361.00 | |||
A20/TNFAIP3 Antibody (B-5): m-IgG1 BP-HRP Bundle | sc-542234 | 200 µg Ab; 20 µg BP | $361.00 | |||
A20/TNFAIP3 (B-5) Neutralizing Peptide | sc-376564 P | 100 µg/0.5 ml | $69.00 | |||
A20/TNFAIP3 Antibody (B-5) X | sc-376564 X | 200 µg/0.1 ml | $322.00 |