A20/TNFAIP3 Antibody (59A426): sc-52910

A20 Antibody (59A426) is a mouse monoclonal IgG1 kappa light chain antibody that detects A20 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-A20 antibody (59A426) is available in a non-conjugated form, allowing for versatile experimental use. A20, also known as TNFAIP3, is a crucial Cys2/Cys2 zinc finger protein that is upregulated in response to various inflammatory stimuli, including tumor necrosis factor (TNF) and interleukin 1 (IL-1). A20 functions as a negative regulator of nuclear factor κB (NFκB) signaling, which is vital for controlling inflammatory responses and cell survival. A20 (59A426) monoclonal antibody helps study how A20 inhibits NFκB activation and terminates inflammatory signals, preventing excessive immune responses that could lead to tissue damage. A20′s structure includes seven zinc finger domains, with four being essential for inhibitory function on TNF-induced NFκB activation. A20 interacts with several key proteins, such as TRAF2, TRAF6, and IκB kinase (IKK) γ, which further enhances modulation of cell death and survival pathways. The discovery of TXBP151, a novel A20-binding protein, suggests that A20 may also have anti-apoptotic properties, making A20 a potential target for therapeutic interventions in various inflammatory diseases.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-A20/TNFAIP3 Antibody (59A426) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-A20/TNFAIP3 Antibody (59A426) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

A20/TNFAIP3 Antibody (59A426) Specifications

Alternate Product Name: TNFAIP3

Product Clone Name: 59A426

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: A20

Epitope Species: human

Product Reactivity/Detection: A20

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for A20/TNFAIP3 Antibody (59A426): N/A

The preferred A20/TNFAIP3 antibody is A20/TNFAIP3 Antibody (A-12): sc-166692.