3pK Antibody (C-12): sc-376743

3pK Antibody (C-12) is a mouse monoclonal IgG2b antibody that detects 3pK in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). 3pK, also known as MAPKAP kinase-3, plays a crucial role in cellular signaling pathways by acting as a downstream effector of the p38 MAP kinase pathway, which is vital for mediating cellular responses to stress and inflammation. The activation of 3pK leads to the phosphorylation of various substrates, influencing processes such as cell growth, differentiation, and apoptosis. Understanding the function of 3pK is important because dysregulation of this kinase has been implicated in several diseases, including cancer and neurodegenerative disorders. The precise regulation of 3pK activity through phosphorylation is essential for maintaining cellular homeostasis, making 3pK a significant target for therapeutic intervention. With an ability to interact with other key proteins in the MAPK signaling cascade, 3pK serves as a pivotal component in the intricate network of cellular signaling, highlighting 3pK′s importance in both normal physiology and disease states.

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3pK Antibody (C-12) References:

1. The murine gamma-herpesvirus-68 MK3 protein causes TAP degradation independent of MHC class I heavy chain degradation.  |  Boname, JM., et al. 2005. Eur J Immunol. 35: 171-9. PMID: 15593121
2. Requirements for the selective degradation of endoplasmic reticulum-resident major histocompatibility complex class I proteins by the viral immune evasion molecule mK3.  |  Wang, X., et al. 2005. J Virol. 79: 4099-108. PMID: 15767411
3. Absence of mutations in the coding sequence of the potential tumor suppressor 3pK in metastatic melanoma.  |  Houben, R., et al. 2005. J Carcinog. 4: 23. PMID: 16367997
4. Murine gammaherpesvirus (MHV) MK3 gene sequence diversity among 72, 4556, and 68 strains.  |  Valovicová, M., et al. 2006. Virus Genes. 33: 51-8. PMID: 16791419
5. The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.  |  Ronkina, N., et al. 2007. Mol Cell Biol. 27: 170-81. PMID: 17030606
6. Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3.  |  Wang, X., et al. 2007. J Cell Biol. 177: 613-24. PMID: 17502423
7. High-resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand.  |  Cheng, R., et al. 2010. Protein Sci. 19: 168-73. PMID: 19937655
8. Theoretical analysis of the binding of potential inhibitors to protein kinases MK2 and MK3.  |  Araújo, PM., et al. 2015. Med Chem. 11: 573-9. PMID: 25665652
9. Genistein nanoformulation promotes selective apoptosis in oral squamous cell carcinoma through repression of 3PK-EZH2 signalling pathway.  |  Dev, A., et al. 2021. Phytomedicine. 80: 153386. PMID: 33113500
10. Mapping of a new MAP kinase activated protein kinase gene (3PK) to human chromosome band 3p21.2 and ordering of 3PK and two cosmid markers in the 3p22-p21 tumour-suppressor region by two-colour fluorescence in situ hybridization.  |  Szeles, A., et al. 1996. Chromosome Res. 4: 310-3. PMID: 8817073

The preferred 3pK antibody is 3pK Antibody (C-4): sc-365148.