3pK Antibody (B-2): sc-376626

3pK Antibody (B-2) is a mouse monoclonal IgG2a antibody that detects 3pK in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). 3pK, also known as MAPKAP kinase-3, plays a crucial role in cellular signaling pathways by acting as a downstream effector of the p38 MAP kinase pathway, which is vital for mediating cellular responses to stress and inflammation. The activation of 3pK through phosphorylation allows regulation of various cellular processes, including gene expression and cell survival, making 3pK an important player in the response to environmental stimuli. Additionally, 3pK interacts with other key proteins, such as the eukaryotic translation initiation factor 4E (eIF4E), which is essential for the initiation of protein synthesis. This interaction highlights 3pK′s significance in linking stress signaling to the regulation of translation, thereby influencing cell growth and differentiation. Anti-3pK antibody (B-2) serves as an invaluable tool for researchers studying the intricate signaling networks that govern cellular responses in human health and disease.

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3pK Antibody (B-2) References:

1. Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity.  |  Neufeld, B., et al. 2000. J Biol Chem. 275: 20239-42. PMID: 10781029
2. Characterization of a novel MK3 splice variant from murine ventricular myocardium.  |  Moïse, N., et al. 2010. Cell Signal. 22: 1502-12. PMID: 20570725
3. Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3.  |  Ehlting, C., et al. 2011. J Biol Chem. 286: 24113-24. PMID: 21586572
4. Crucial roles of the protein kinases MK2 and MK3 in a mouse model of glomerulonephritis.  |  Guess, AJ., et al. 2013. PLoS One. 8: e54239. PMID: 23372691
5. MAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection.  |  Köther, K., et al. 2014. FASEB J. 28: 4235-46. PMID: 24935968
6. Differential regulation of cytokine and chemokine expression by MK2 and MK3 in airway smooth muscle cells.  |  Ba, M., et al. 2018. Pulm Pharmacol Ther. 53: 12-19. PMID: 30205157
7. Cooperative and distinct functions of MK2 and MK3 in the regulation of the macrophage transcriptional response to lipopolysaccharide.  |  Ehlting, C., et al. 2019. Sci Rep. 9: 11021. PMID: 31363109
8. Network pharmacology and transcriptomic profiling elucidate the therapeutic effects of Ranunculus ternatus Thunb on liver fibrosis via MK3-NF-κB inhibition.  |  Han, L., et al. 2024. Aging (Albany NY). 16: 4759-4777. PMID: 38461449
9. 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region.  |  Sithanandam, G., et al. 1996. Mol Cell Biol. 16: 868-76. PMID: 8622688
10. A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.  |  Clifton, AD., et al. 1996. FEBS Lett. 392: 209-14. PMID: 8774846

The preferred 3pK antibody is 3pK Antibody (C-4): sc-365148.