3BP2 Antibody (C-11): sc-377020
- 3BP2 Antibody (C-11) is a mouse monoclonal IgG2b κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 3-29 at the N-terminus of 3BP2 of human origin
- recommended for detection of 3BP2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and canine and porcine
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for 3BP2 Antibody (C-11) for WB and IHC(P) applications. These reagents are now offered in bundles with 3BP2 Antibody (C-11) (see ordering information below).
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3BP2 Antibody (C-11) is a mouse monoclonal IgG2b antibody that detects 3BP2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). 3BP2 is a crucial Syk family kinase-interacting protein (SKIP) that plays a significant role in T cell signaling, particularly in the activation and regulation of immune responses. 3BP2 is primarily expressed in spleen and peripheral blood leukocytes, where 3BP2 is involved in the translocation from the cytoplasm to the membrane upon T cell receptor stimulation. 3BP2′s ability to associate with T cell receptor protein tyrosine kinase complexes is vital for function, as 3BP2 selectively binds to Flt3/Flk2 receptors and phosphorylated proteins such as Syk, LAT, and ZAP-70. This interaction is essential for the activation of transcription factors like NFAT and AP-1, leading to the upregulation of the IL-2 gene promoter, which is critical for T cell proliferation and differentiation. Anti-3BP2 antibody (C-11) is an invaluable tool for researchers studying T cell signaling pathways and their implications in immune responses and related diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3BP2 Antibody (C-11) | sc-377020 | 200 µg/ml | $322.00 | |||
3BP2 Antibody (C-11): m-IgGκ BP-HRP Bundle | sc-535538 | 200 µg Ab; 40 µg BP | $361.00 | |||
3BP2 Antibody (C-11): m-IgG2b BP-HRP Bundle | sc-549447 | 200 µg Ab; 10 µg BP | $361.00 | |||
3BP2 (C-11) Neutralizing Peptide | sc-377020 P | 100 µg/0.5 ml | $69.00 |