3BP1 Antibody (A-5): sc-376720
- 3BP1 Antibody (A-5) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 317-351 within an internal region of 3BP1 of human origin
- recommended for detection of 3BP1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for 3BP1 Antibody (A-5) for WB applications. These reagents are now offered in bundles with 3BP1 Antibody (A-5) (see ordering information below).
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3BP1 Antibody (A-5) is a mouse monoclonal IgG2a antibody that detects 3BP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). 3BP1, or SH3 domain-binding protein 1, is a 701 amino acid protein that plays a crucial role in cellular signaling by acting as a GTPase-activating protein (GAP) for Rac-related proteins, which are essential for regulating various cellular processes, including cytoskeletal dynamics and cell migration. 3BP1′s ability to bind to the SH3 domains of key signal transduction pathway proteins, particularly SRC-1 and GRB2, highlights 3BP1′s importance in modulating signaling cascades that influence cell behavior. Additionally, 3BP1 is expressed in two isoforms due to alternative splicing, featuring one BAR domain and one Rho-GAP domain, which contribute to 3BP1′s functional versatility. By inhibiting platelet-derived growth factor (PDGF)-induced membrane ruffling mediated by Rac, 3BP1 serves as a critical regulator of actin cytoskeleton organization, making 3BP1 a significant target for studies related to cell motility and cancer progression.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3BP1 Antibody (A-5) | sc-376720 | 200 µg/ml | $322.00 | |||
3BP1 Antibody (A-5): m-IgG Fc BP-HRP Bundle | sc-540635 | 200 µg Ab; 10 µg BP | $361.00 | |||
3BP1 Antibody (A-5): m-IgG2a BP-HRP Bundle | sc-546940 | 200 µg Ab; 10 µg BP | $361.00 | |||
3BP1 (A-5) Neutralizing Peptide | sc-376720 P | 100 µg/0.5 ml | $69.00 |