26S Proteasome p54 Antibody (170): sc-65747

26S Proteasome p54 Antibody (170) is a mouse monoclonal IgG2b antibody that detects 26S proteasome p54 in various species by western blotting (WB) and immunoprecipitation (IP). 26S proteasome p54, also known as Rpn10 in yeast and S5a in humans, is a crucial component of the 19S regulatory complex of the 26S proteasome, which is essential for the degradation of ubiquitinated proteins within eukaryotic cells. 26S proteasome p54 plays a significant role in maintaining cellular homeostasis by regulating the turnover of proteins involved in various biological processes, including cell cycle progression, signal transduction, and stress responses. 26S proteasome p54 is particularly important due to multiubiquitin binding capability, which is vital for recognizing and processing substrates tagged for degradation. Additionally, zinc can lead to the dissociation of p54 from the 19S complex, resulting in the loss of peptidase activity, highlighting the delicate balance of protein interactions within the proteasome. 26S proteasome p54 interacts with non-proteasomal proteins such as HSP 82, Smt3, and UBC9, which may influence function and stability, making p54 a key player in the intricate network of cellular protein regulation.

The preferred 26S Proteasome p54 antibody is 26S Proteasome p54 Antibody (28): sc-65748.