26S Proteasome α Antibody (IIG7): sc-65755
- 26S Proteasome α Antibody (IIG7) is a mouse monoclonal IgG1 κ 26S Proteasome α antibody, cited in 19 publications, provided at 200 µg/ml
- raised against 26S Proteasome purified from embryos of Drosophila melanogaster origin
- 26S Proteasome alpha Antibody (IIG7) is recommended for detection of α subunit of the 20S catalytic core of the 26S Proteasome of Drosophila melanogaster origin by WB and IP
- Anti-26S Proteasome alpha Antibody (IIG7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for 26S Proteasome α Antibody (IIG7) for WB applications. These reagents are now offered in bundles with 26S Proteasome α Antibody (IIG7) (see ordering information below).
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26S Proteasome α Antibody (IIG7) is a mouse monoclonal IgG1 kappa light chain antibody that detects the 26S Proteasome alpha protein of Drosophila melanogaster origin by western blotting (WB) and immunoprecipitation (IP). Anti-26S Proteasome α antibody (IIG7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. 26S proteasome is a crucial component of the ubiquitin-proteasome system, responsible for degrading ubiquitinated proteins, which maintains cellular homeostasis and regulates various biological processes such as cell cycle progression, apoptosis, and responses to oxidative stress. This protein complex comprises over 30 different subunits, with α subunits forming the outer rings of the 20S core, which restricts access to the catalytic chamber and plays a vital role in assembly and stability of the proteasome. Assembly of this large complex is ATP-dependent, and due to its size, can disassociate into subcomplexes, including a 20S core and two 19S regulatory complexes. Understanding the structure and function of 26S proteasome helps elucidate its role in cellular regulation and implications in various diseases, including cancer and neurodegenerative disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
26S Proteasome α Antibody (IIG7) References:
- Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. | Wang, X., et al. 2007. Biochemistry. 46: 3553-65. PMID: 17323924
- Proteasome as an emerging therapeutic target in cancer. | Zavrski, I., et al. 2007. Curr Pharm Des. 13: 471-85. PMID: 17348844
- Ubiquitin dependent and independent protein degradation in the regulation of cellular polyamines. | Kahana, C. 2007. Amino Acids. 33: 225-30. PMID: 17404802
- Aging perturbs 26S proteasome assembly in Drosophila melanogaster. | Vernace, VA., et al. 2007. FASEB J. 21: 2672-82. PMID: 17413001
- beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. | Li, X., et al. 2007. EMBO J. 26: 2339-49. PMID: 17431397
- Characterization of the VIER F-BOX PROTEINE genes from Arabidopsis reveals their importance for plant growth and development. | Schwager, KM., et al. 2007. Plant Cell. 19: 1163-78. PMID: 17435085
- Rpn13p and Rpn14p are involved in the recognition of ubiquitinated Gcn4p by the 26S proteasome. | Seong, KM., et al. 2007. FEBS Lett. 581: 2567-73. PMID: 17499717
- Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: enhanced activity for degradation of abnormal protein. | Kwak, MK., et al. 2007. Life Sci. 80: 2411-20. PMID: 17521679
- Automated cryoelectron microscopy of 'single particles' applied to the 26S proteasome. | Nickell, S., et al. 2007. FEBS Lett. 581: 2751-6. PMID: 17531228
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
26S Proteasome α Antibody (IIG7) | sc-65755 | 200 µg/ml | $322.00 | |||
26S Proteasome α Antibody (IIG7): m-IgG Fc BP-HRP Bundle | sc-526966 | 200 µg Ab; 10 µg BP | $361.00 | |||
26S Proteasome α Antibody (IIG7): m-IgG1 BP-HRP Bundle | sc-532339 | 200 µg Ab; 20 µg BP | $361.00 | |||
26S Proteasome α Antibody (IIG7) AC | sc-65755 AC | 500 µg/ml, 25% agarose | $424.00 | |||
26S Proteasome α Antibody (IIG7) HRP | sc-65755 HRP | 200 µg/ml | $322.00 | |||
26S Proteasome α Antibody (IIG7) FITC | sc-65755 FITC | 200 µg/ml | $336.00 | |||
26S Proteasome α Antibody (IIG7) PE | sc-65755 PE | 200 µg/ml | $349.00 | |||
26S Proteasome α Antibody (IIG7) Alexa Fluor® 488 | sc-65755 AF488 | 200 µg/ml | $364.00 | |||
26S Proteasome α Antibody (IIG7) Alexa Fluor® 546 | sc-65755 AF546 | 200 µg/ml | $364.00 | |||
26S Proteasome α Antibody (IIG7) Alexa Fluor® 594 | sc-65755 AF594 | 200 µg/ml | $364.00 | |||
26S Proteasome α Antibody (IIG7) Alexa Fluor® 647 | sc-65755 AF647 | 200 µg/ml | $364.00 | |||
26S Proteasome α Antibody (IIG7) Alexa Fluor® 680 | sc-65755 AF680 | 200 µg/ml | $364.00 | |||
26S Proteasome α Antibody (IIG7) Alexa Fluor® 790 | sc-65755 AF790 | 200 µg/ml | $364.00 |