20S Proteasome α2 Antibody (B-7): sc-390888
- 20S Proteasome α2 Antibody (B-7) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 202-229 at the C-terminus of 20S Proteasome α2 of human origin
- recommended for detection of 20S Proteasome α2 of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for 20S Proteasome α2 Antibody (B-7) for WB applications. These reagents are now offered in bundles with 20S Proteasome α2 Antibody (B-7) (see ordering information below).
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20S Proteasome α2 Antibody (B-7) is a mouse monoclonal IgG1 antibody that detects 20S Proteasome α2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). 20S Proteasome α2 is a crucial component of the 26S proteasome complex, which plays a vital role in maintaining cellular homeostasis by degrading unnecessary or damaged proteins through proteolysis. This process is essential for regulating various cellular functions, including the cell cycle, signal transduction, and the response to oxidative stress. The 20S core particle, where the actual degradation occurs, is composed of multiple subunits that form a cylindrical structure, allowing for the selective entry of target proteins while preventing unregulated access. The α subunits serve as structural components, creating docking sites for regulatory particles, while the β subunits are primarily responsible for the catalytic activity necessary for protein degradation. The proper functioning of the proteasome is critical for cellular health, as dysregulation can lead to various diseases, including cancer and neurodegenerative disorders. Anti-20S Proteasome α2 antibody (B-7) is an invaluable tool for researchers studying proteasome function and its implications in health and disease.
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20S Proteasome α2 Antibody (B-7) References:
- Orientation of the 19S regulator relative to the 20S core proteasome: an immunoelectron microscopic study. | Kopp, F. and Kuehn, L. 2003. J Mol Biol. 329: 9-14. PMID: 12742014
- Differential regulation of the PanA and PanB proteasome-activating nucleotidase and 20S proteasomal proteins of the haloarchaeon Haloferax volcanii. | Reuter, CJ., et al. 2004. J Bacteriol. 186: 7763-72. PMID: 15516591
- Mapping the murine cardiac 26S proteasome complexes. | Gomes, AV., et al. 2006. Circ Res. 99: 362-71. PMID: 16857966
- A new method of purification of proteasome substrates reveals polyubiquitination of 20 S proteasome subunits. | Ventadour, S., et al. 2007. J Biol Chem. 282: 5302-9. PMID: 17189251
- TLR4 mediates the impairment of ubiquitin-proteasome and autophagy-lysosome pathways induced by ethanol treatment in brain. | Pla, A., et al. 2014. Cell Death Dis. 5: e1066. PMID: 24556681
- Regulating the 20S proteasome ubiquitin-independent degradation pathway. | Ben-Nissan, G. and Sharon, M. 2014. Biomolecules. 4: 862-84. PMID: 25250704
- Pyrazolones Activate the Proteasome by Gating Mechanisms and Protect Neuronal Cells from β-Amyloid Toxicity. | Santoro, AM., et al. 2020. ChemMedChem. 15: 302-316. PMID: 31797568
- Updated Review and Perspective on 20S Proteasome Inhibitors in the Treatment of Lung Cancer. | Rohondia, SO., et al. 2020. Curr Cancer Drug Targets. 20: 392-409. PMID: 32101123
- A Role for the Proteasome Alpha2 Subunit N-Tail in Substrate Processing. | Sahu, I., et al. 2023. Biomolecules. 13: PMID: 36979414
- Dissecting the assembly pathway of the 20S proteasome. | Zühl, F., et al. 1997. FEBS Lett. 418: 189-94. PMID: 9414124
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
20S Proteasome α2 Antibody (B-7) | sc-390888 | 200 µg/ml | $316.00 | |||
20S Proteasome α2 Antibody (B-7): m-IgG Fc BP-HRP Bundle | sc-538108 | 200 µg Ab; 10 µg BP | $354.00 | |||
20S Proteasome α2 Antibody (B-7): m-IgGκ BP-HRP Bundle | sc-535659 | 200 µg Ab; 40 µg BP | $354.00 | |||
20S Proteasome α2 Antibody (B-7): m-IgG1 BP-HRP Bundle | sc-545526 | 200 µg Ab; 20 µg BP | $354.00 | |||
20S Proteasome α2 (B-7) Neutralizing Peptide | sc-390888 P | 100 µg/0.5 ml | $68.00 |