17β-HSD8 Antibody (G-4): sc-515239
- 17β-HSD8 Antibody (G-4) is a mouse monoclonal IgG2a κ 17β-HSD8 antibody provided at 200 µg/ml
- raised against amino acids 1-261 representing full length 17β-HSD8 of human origin
- 17 beta-HSD8 Antibody (G-4) is recommended for detection of 17β-HSD8 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-17 beta-HSD8 Antibody (G-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for 17β-HSD8 Antibody (G-4) for WB applications. These reagents are now offered in bundles with 17β-HSD8 Antibody (G-4) (see ordering information below).
17β-HSD8 Antibody (G-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects 17β-HSD8 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-17β-HSD8 antibody (G-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. 17β-HSD8, also known as 17 beta-hydroxysteroid dehydrogenase type 8, plays a crucial role in regulating steroid hormone availability within tissues by converting active steroids, such as estradiol and testosterone, into inactive forms through oxidative activity. This enzymatic function is vital for maintaining hormonal balance, as dysregulation can lead to abnormal steroid levels, potentially resulting in conditions such as recessive renal cystic disease and underdevelopment of the urogenital system. 17β-HSD8 is predominantly expressed in the placenta, endometrium, and prostate, with additional expression in the liver and pancreas, while lowest levels are found in the testis, ovary, and kidney. Precise localization and activity of 17β-HSD8 are essential for normal reproductive and metabolic functions, making 17β-HSD8 a significant target for research in endocrinology and reproductive health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
17β-HSD8 Antibody (G-4) References:
- Arrested testis development in the cpk mouse may be the result of abnormal steroid metabolism. | Aziz, N., et al. 2001. Mol Cell Endocrinol. 171: 83-8. PMID: 11165015
- Genes in the HLA region indicative for head and neck squamous cell carcinoma. | Reinders, J., et al. 2007. Mol Immunol. 44: 848-55. PMID: 16750857
- Molecular cloning of bovine FABGL gene and its effects on bovine bioeconomic traits. | Ma, Y., et al. 2006. Yi Chuan Xue Bao. 33: 1096-104. PMID: 17185169
- Transcriptional regulation of the human type 8 17beta-hydroxysteroid dehydrogenase gene by C/EBPbeta. | Villar, J., et al. 2007. J Steroid Biochem Mol Biol. 105: 131-9. PMID: 17583490
- cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region. | Ando, A., et al. 1996. Genomics. 35: 600-2. PMID: 8812499
- Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes. | Kikuti, YY., et al. 1997. Genomics. 42: 422-35. PMID: 9205114
- Characterization of Ke 6, a new 17beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues. | Fomitcheva, J., et al. 1998. J Biol Chem. 273: 22664-71. PMID: 9712896
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
17β-HSD8 Antibody (G-4) | sc-515239 | 200 µg/ml | $322.00 | |||
17β-HSD8 Antibody (G-4): m-IgG Fc BP-HRP Bundle | sc-526422 | 200 µg Ab; 10 µg BP | $361.00 | |||
17β-HSD8 Antibody (G-4): m-IgG2a BP-HRP Bundle | sc-546637 | 200 µg Ab; 10 µg BP | $361.00 | |||
17β-HSD8 Antibody (G-4) AC | sc-515239 AC | 500 µg/ml, 25% agarose | $424.00 | |||
17β-HSD8 Antibody (G-4) HRP | sc-515239 HRP | 200 µg/ml | $322.00 | |||
17β-HSD8 Antibody (G-4) FITC | sc-515239 FITC | 200 µg/ml | $336.00 | |||
17β-HSD8 Antibody (G-4) PE | sc-515239 PE | 200 µg/ml | $349.00 | |||
17β-HSD8 Antibody (G-4) Alexa Fluor® 488 | sc-515239 AF488 | 200 µg/ml | $364.00 | |||
17β-HSD8 Antibody (G-4) Alexa Fluor® 546 | sc-515239 AF546 | 200 µg/ml | $364.00 | |||
17β-HSD8 Antibody (G-4) Alexa Fluor® 594 | sc-515239 AF594 | 200 µg/ml | $364.00 | |||
17β-HSD8 Antibody (G-4) Alexa Fluor® 647 | sc-515239 AF647 | 200 µg/ml | $364.00 | |||
17β-HSD8 Antibody (G-4) Alexa Fluor® 680 | sc-515239 AF680 | 200 µg/ml | $364.00 | |||
17β-HSD8 Antibody (G-4) Alexa Fluor® 790 | sc-515239 AF790 | 200 µg/ml | $364.00 |