15-LO2 Antibody (H-6): sc-166387
- 15-LO2 Antibody (H-6) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 423-452 within an internal region of 15-LO2 of human origin
- recommended for detection of 15-LO2 splice variants a, b and c of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for 15-LO2 Antibody (H-6) for WB applications. These reagents are now offered in bundles with 15-LO2 Antibody (H-6) (see ordering information below).
15-LO2 Antibody (H-6) is a mouse monoclonal IgG2b antibody that detects 15-lipoxygenase type II (15-LO2) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). 15-LO2 plays a crucial role in the metabolism of arachidonic acid, converting it into 15S-hydroperoxyeicosatetraenoic acid, which is a key intermediate in the biosynthesis of bioactive lipids involved in inflammatory responses and cellular signaling. The proper functioning of 15-LO2 is vital for maintaining homeostasis in tissues, particularly in the cornea, lung, hair, and prostate, where 15-LO2 is predominantly expressed. Dysregulation of 15-LO2 has been implicated in various pathological conditions, including atherosclerosis and cancer, highlighting 15-LO2′s importance in both physiological and pathological processes. Expression of 15-LO2 is tightly regulated and can be influenced by cytokines such as IL-4 and IL-13, which are known to transactivate the 15-LO gene, thereby affecting 15-LO2 activity and expression levels in different cell types. Anti-15-LO2 antibody (H-6) enables researchers to gain valuable insights into the role of this enzyme in health and disease, making anti-15-LO2 antibody (H-6) an essential tool for studies focused on lipid metabolism and its implications in various biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
15-LO2 Antibody (H-6) | sc-166387 | 200 µg/ml | $322.00 | |||
15-LO2 Antibody (H-6): m-IgG Fc BP-HRP Bundle | sc-540093 | 200 µg Ab; 10 µg BP | $361.00 | |||
15-LO2 Antibody (H-6): m-IgG2b BP-HRP Bundle | sc-549772 | 200 µg Ab; 10 µg BP | $361.00 | |||
15-LO2 (H-6) Neutralizing Peptide | sc-166387 P | 100 µg/0.5 ml | $69.00 |