15-LO2 Antibody (D-9): sc-271290

15-LO2 Antibody (D-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects 15-LO2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-15-LO2 antibody (D-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The 15-lipoxygenase type II (15-LO2) protein plays a crucial role in the metabolism of arachidonic acid, converting it into 15S-hydroperoxyeicosatetraenoic acid, which is essential for the production of bioactive lipid mediators involved in various physiological processes. 15-LO2 is primarily located in the cytoplasm and is expressed in specific tissues such as the cornea, lung, hair, and prostate, highlighting its importance in tissue-specific functions and responses. Cytokines like IL-4 and IL-13 tightly control 15-LO2 regulation and can transactivate the 15-LO gene, thereby affecting expression levels. Dysregulation of 15-LO2 has been implicated in several pathological conditions, including atherosclerosis, inflammation, and cancer progression, particularly in prostate cancer where 15-LO2 modulates insulin-like growth factor 1 receptor expression and activation. Understanding the function and regulation of 15-LO2 is vital for elucidating its role in health and disease, making 15-LO2 (D-9) antibody an invaluable tool for researchers studying these processes.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-15-LO2 Antibody (D-9) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-15-LO2 Antibody (D-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

15-LO2 Antibody (D-9) Specifications

Alternate Product Name: 15-LO2

Product Clone Name: D-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 423-452

Epitope Target: 15-LO2

Epitope Species: human

Product Reactivity/Detection: 15-LO2 splice variants a, b and c

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for 15-LO2 Antibody (D-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred 15-LO2 antibody is 15-LO2 Antibody (F-10): sc-376795.