p-CD3-ζ Antibody (96.Tyr 111): sc-135759

p-CD3-ζ Antibody (96.Tyr 111) is a mouse monoclonal IgG1 antibody that detects p-CD3-ζ in mouse, rat, and human samples through applications such as western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). p-CD3-ζ plays a crucial role in T cell activation by forming part of the CD3 complex, which is essential for transmitting signals from the T cell receptor upon antigen recognition. p-CD3-ζ is primarily located in the plasma membrane of T cells, where p-CD3-ζ associates with the T cell receptor and other signaling molecules. p-CD3-ζ presence at the cell surface is vital for the initiation of T cell responses, as p-CD3-ζ helps to propagate the activation signal that leads to T cell proliferation and differentiation. Additionally, p-CD3-ζ contains immunoreceptor tyrosine-based activation motifs (ITAMs) that are critical for recruiting and activating downstream signaling proteins, thereby amplifying the immune response. p-CD3-ζ interaction with various kinases, such as ZAP-70, underscores p-CD3-ζ importance in the signaling cascade that ultimately results in T cell activation and function. anti-p-CD3-ζ antibody (96.Tyr 111) is an invaluable tool for researchers studying T cell biology and immune responses.

The preferred CD3-ζ antibody is CD3-ζ Antibody (6B10.2): sc-1239.