IRF3 Antibody (SL-14): sc-33642
- IRF3 Antibody (SL-14) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against recombinant IRF-3 fusion protein corresponding to human IRF-3
- recommended for detection of IRF-3 of human origin by WB, IP, IF and IHC(P)
- TransCruz reagent for Gel Supershift and ChIP applications (sc-33642 X, 200 µg/0.1 ml)
- See IRF3 (SL-12): sc-33641 for IRF3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IRF3 Antibody (SL-14) for WB and IHC(P) applications. These reagents are now offered in bundles with IRF3 Antibody (SL-14) (see ordering information below).
IRF-3 Antibody (SL-14) is a mouse monoclonal IgG1 kappa light chain antibody engineered to target the Interferon Regulatory Factor 3 (IRF-3) protein with exceptional precision. Anti-IRF-3 antibody (SL-14) is raised against a recombinant IRF-3 fusion protein corresponding to the human IRF-3 sequence, ensuring robust detection of IRF-3 in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). IRF-3, also called IIAE7, is a pivotal transcription factor primarily located in the cytoplasm of cells under basal conditions, where IRF-3 remains inactive. Upon detection of viral infections or other pathogenic stimuli, IRF-3 undergoes phosphorylation, which triggers dimerization and translocation into the nucleus. Once in the nucleus, IRF-3 binds to specific DNA elements to activate the transcription of type I interferons, such as IFN-β, and other antiviral genes, orchestrating a critical innate immune response. The precise localization and activation of IRF-3 are essential for initiating effective antiviral defenses and regulating immune signaling pathways. IRF-3 monoclonal antibody (SL-14) enables researchers to accurately monitor the spatial and temporal dynamics of IRF-3 within cells, facilitating a deeper understanding of IRF-3′s role in immune regulation, pathogen response, and the molecular mechanisms underlying various diseases. Anti-IRF-3 antibody (SL-14) is an invaluable tool for studies aiming to elucidate the complex interactions and functions of IRF-3 in maintaining cellular homeostasis and combating infections.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IRF3 Antibody (SL-14) | sc-33642 | 200 µg/ml | $322.00 | |||
IRF3 Antibody (SL-14): m-IgG Fc BP-HRP Bundle | sc-536765 | 200 µg Ab; 10 µg BP | $361.00 | |||
IRF3 Antibody (SL-14): m-IgGκ BP-HRP Bundle | sc-533929 | 200 µg Ab; 40 µg BP | $361.00 | |||
IRF3 Antibody (SL-14): m-IgG1 BP-HRP Bundle | sc-544808 | 200 µg Ab; 20 µg BP | $361.00 | |||
IRF3 Antibody (SL-14) X | sc-33642 X | 200 µg/0.1 ml | $322.00 |