Integrin α5/ITGA5/CD49e Antibody (B-4): sc-166681

Integrin α5 Antibody (B-4) is a mouse monoclonal IgG1 antibody that detects Integrin α5 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Integrin α5 plays a crucial role in cell adhesion and signaling, primarily by forming heterodimers with the β1 subunit to create the α5β1 integrin receptor, which is essential for binding to extracellular matrix components such as fibronectin. This interaction is vital for numerous biological processes, including cell migration, proliferation, and differentiation, making anti-Integrin α5 antibody (B-4) a key tool for studying tissue development and repair. Integrin α5′s ability to mediate cell adhesion not only facilitates the structural integrity of tissues but also influences cellular responses to external stimuli, thereby impacting processes such as wound healing and immune responses. Furthermore, the dynamic regulation of Integrin α5 expression and its interactions with other signaling molecules underscore its importance in maintaining cellular homeostasis and responding to pathological conditions. Integrin α5 monoclonal antibody (B-4) serves as an invaluable tool for researchers investigating the intricate roles of integrins in health and disease.

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Integrin α5/ITGA5/CD49e Antibody (B-4) References:

1. Binding of soluble fibronectin to integrin alpha5 beta1 - link to focal adhesion redistribution and contractile shape.  |  Huveneers, S., et al. 2008. J Cell Sci. 121: 2452-62. PMID: 18611961
2. Integrin expression profiling identifies integrin alpha5 and beta1 as prognostic factors in early stage non-small cell lung cancer.  |  Dingemans, AM., et al. 2010. Mol Cancer. 9: 152. PMID: 20565758
3. Fibronectin fragment activation of ERK increasing integrin α₅ and β₁ subunit expression to degenerate nucleus pulposus cells.  |  Xia, M. and Zhu, Y. 2011. J Orthop Res. 29: 556-61. PMID: 21337395
4. N-Glycosylation of integrin α5 acts as a switch for EGFR-mediated complex formation of integrin α5β1 to α6β4.  |  Hang, Q., et al. 2016. Sci Rep. 6: 33507. PMID: 27641064
5. A Key Regulator of Cell Adhesion: Identification and Characterization of Important N-Glycosylation Sites on Integrin α5 for Cell Migration.  |  Hang, Q., et al. 2017. Mol Cell Biol. 37: PMID: 28167607
6. Complexes formed with integrin-α5 and KCNB1 potassium channel wild type or epilepsy-susceptibility variants modulate cellular plasticity via Ras and Akt signaling.  |  Yu, W., et al. 2019. FASEB J. 33: 14680-14689. PMID: 31682765
7. Polymer Thin Film Promotes Tumor Spheroid Formation via JAK2-STAT3 Signaling Primed by Fibronectin-Integrin α5 and Sustained by LMO2-LDB1 Complex.  |  Seo, S., et al. 2022. Biomedicines. 10: PMID: 36359204
8. Expression of the integrin alpha5 subunit and its mediated cell adhesion in hepatocellular carcinoma.  |  Yao, M., et al. 1997. J Cancer Res Clin Oncol. 123: 435-40. PMID: 9292706
9. Integrin alpha5 is expressed on human luteinizing granulosa cells during corpus luteum formation, and its expression is enhanced by human chorionic gonadotrophin in vitro.  |  Honda, T., et al. 1997. Mol Hum Reprod. 3: 979-84. PMID: 9433924
10. Cross-talk between insulin receptor and integrin alpha5 beta1 signaling pathways.  |  Guilherme, A., et al. 1998. J Biol Chem. 273: 22899-903. PMID: 9722509

The preferred Integrin α5/ITGA5/CD49e antibody is Integrin α5/ITGA5/CD49e Antibody (P1D6): sc-13547.