elastin Antibody (B-10): sc-166352
- elastin Antibody (B-10) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 431-730 of elastin of human origin
- recommended for detection of elastin of human origin by WB, IP, IF and ELISA
- See elastin (BA-4): sc-58756 for elastin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for elastin Antibody (B-10) for WB applications. These reagents are now offered in bundles with elastin Antibody (B-10) (see ordering information below).
QUICK LINKS
SEE ALSO...
Elastin Antibody (B-10) is a mouse monoclonal IgG1 antibody that detects elastin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Elastin plays a crucial role in maintaining the elasticity and resilience of connective tissues, particularly in the extracellular matrix of arteries, where elastin regulates smooth muscle proliferation and stabilizes arterial structure during development. The unique structure of elastin, characterized by a high content of glycine, proline, and hydrophobic residues, along with distinctive lysine-derived crosslinks, such as desmosines, allows elastin to form a rubber-like network that is essential for the proper functioning of tissues that undergo stretching and recoil. As individuals age, the cross-linking of collagen fibers with elastin can lead to a decrease in tissue elasticity, contributing to various age-related disorders. Furthermore, deficiencies in elastin are linked to serious conditions such as supravalvular aortic stenosis and Williams-Beuren syndrome, highlighting the importance of elastin in vascular health and development. The human elastin gene is located on chromosome 7q11.23, underscoring its genetic significance in health and disease. Anti-elastin antibody (B-10) is an invaluable tool for researchers studying the dynamics of elastin in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
elastin Antibody (B-10) References:
- Elastin as a nonthrombogenic biomaterial. | Waterhouse, A., et al. 2011. Tissue Eng Part B Rev. 17: 93-9. PMID: 21166482
- Elastin signaling in wound repair. | Almine, JF., et al. 2012. Birth Defects Res C Embryo Today. 96: 248-57. PMID: 23109320
- Elastin degradation and ensuing inflammation as emerging keys to atherosclerosis. | Hirsch, E. and Ghigo, A. 2014. Cardiovasc Res. 102: 1-2. PMID: 24518143
- Elastin peptides in aging and pathological conditions. | Baud, S., et al. 2013. Biomol Concepts. 4: 65-76. PMID: 25436566
- Elastin structure and its involvement in skin photoageing. | Weihermann, AC., et al. 2017. Int J Cosmet Sci. 39: 241-247. PMID: 27731897
- The liquid structure of elastin. | Rauscher, S. and Pomès, R. 2017. Elife. 6: PMID: 29120326
- Elastin is heterogeneously cross-linked. | Schräder, CU., et al. 2018. J Biol Chem. 293: 15107-15119. PMID: 30108173
- Recombination and Purification of Elastin-Like Polypeptides. | Zhao, C., et al. 2021. Methods Mol Biol. 2347: 97-103. PMID: 34472058
- Mechanical Properties and Functions of Elastin: An Overview. | Trębacz, H. and Barzycka, A. 2023. Biomolecules. 13: PMID: 36979509
- Elastases and elastin degradation. | Werb, Z., et al. 1982. J Invest Dermatol. 79 Suppl 1: 154s-159s. PMID: 7045242
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
elastin Antibody (B-10) | sc-166352 | 200 µg/ml | $322.00 | |||
elastin Antibody (B-10): m-IgG Fc BP-HRP Bundle | sc-537477 | 200 µg Ab; 10 µg BP | $361.00 | |||
elastin Antibody (B-10): m-IgGκ BP-HRP Bundle | sc-534756 | 200 µg Ab; 40 µg BP | $361.00 | |||
elastin Antibody (B-10): m-IgG1 BP-HRP Bundle | sc-545199 | 200 µg Ab; 20 µg BP | $361.00 |