MAF1 Inhibitors
MAF1 inhibitors belong to a class of chemical compounds designed to target and modulate the activity of the MAF1 (RNA polymerase III repressor) protein. MAF1 is a conserved, multifunctional protein found in eukaryotes, including humans. Its primary role is to regulate the transcription of genes transcribed by RNA polymerase III (Pol III), such as those involved in the synthesis of small RNAs like tRNAs and 5S rRNA. MAF1 achieves this by binding to Pol III and inhibiting its activity, thereby preventing the transcription of these small RNA genes. Inhibitors of MAF1 are developed to interact with this protein, disrupting its ability to repress Pol III transcription and influencing the synthesis of small RNAs in the cell.
These inhibitors are typically small molecules or compounds designed to bind to MAF1, interfering with its interactions with RNA polymerase III and other regulatory factors. By doing so, MAF1 inhibitors may modulate the transcriptional activity of Pol III, ultimately affecting the levels of various small RNAs. Research into MAF1 inhibitors can provide valuable insights into the regulation of gene expression, particularly for genes transcribed by RNA polymerase III, and their roles in cellular processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, might affect MAF1 expression by influencing cellular growth and metabolic pathways, as mTOR signaling is known to regulate RNA polymerase III activity. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
Torin 1, another mTOR inhibitor, could potentially affect MAF1 expression by altering the mTOR pathway, which is involved in the regulation of RNA polymerase III and associated proteins. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a PI3K inhibitor, might influence MAF1 expression by modulating the PI3K/Akt/mTOR pathway, affecting the cellular signals that regulate RNA polymerase III transcription. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, a PI3K inhibitor, could affect MAF1 expression by altering PI3K/Akt/mTOR signaling, which plays a role in the regulation of RNA polymerase III and its associated factors. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin, an AMPK activator, could potentially influence MAF1 expression by affecting cellular energy status and AMPK-related pathways, which are known to regulate RNA polymerase III activity. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine, an alkaloid, could affect MAF1 expression by impacting cellular metabolism and signaling pathways, potentially influencing the regulation of RNA polymerase III activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, might indirectly affect MAF1 expression by modulating cellular stress response pathways and potentially influencing RNA polymerase III transcription. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG), a green tea polyphenol, could potentially influence MAF1 expression through its effects on cellular antioxidant responses and signaling pathways related to RNA synthesis. | ||||||