Date published: 2026-5-7

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HDAC8 Antibodies

Santa Cruz Biotechnology provides a broad selection of HDAC8 monoclonal antibodies for investigating histone deacetylase 8 in various biological processes. HDAC8 monoclonal antibodies are validated for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Histone deacetylase 8 functions as a crucial enzyme that regulates gene expression by removing acetyl groups from histone proteins, resulting in chromatin condensation and transcriptional repression. HDAC8 dysregulation has been linked to various diseases, including cancer and neurodegenerative disorders, making it an important target for therapeutic intervention. Understanding HDAC8 function is vital for uncovering its role in cellular processes and disease mechanisms. HDAC8 monoclonal antibodies enable precise detection and analysis of histone modification patterns across different experimental conditions. Researchers can utilize HDAC8 monoclonal antibodies to track protein localization, measure expression levels, and study protein-protein interactions. Santa Cruz Biotechnology monoclonal antibodies support researchers worldwide in advancing scientific understanding of histone modification and its impact on human health.

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HDAC8 Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

Histone Deacetylase 8 Antibody (E-5)

sc-17778mouse IgG2b κ1-145 (h)WB, IP, IF, IHC(P), ELISAh
16
(7)

Histone Deacetylase 8 Antibody (F-9)

sc-374180mouse IgG3 κ2-28 (h)WB, IP, IF, ELISAm, r, h
4
(1)

Histone Deacetylase 8 (HDAC8) Antibody (B-4)

sc-365620mouse IgG12-28 (h)WB, IP, IF, IHC(P), ELISAh
4
(3)

Histone Deacetylase 8 Antibody (HDAC8-48)

sc-56687mouse IgG1FL (h)WB, IP, ELISAh

new

(1)

HDAC8 CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Histone Deacetylase 8 (HDAC8) CRISPR/Cas9 KO Plasmid (h)

sc-400757hGene KnockoutGFP0
(0)

Histone Deacetylase 8 (HDAC8) HDR Plasmid (h)

sc-400757-HDRhHomology Directed RepairPuromycin0
(0)

Histone Deacetylase 8 (HDAC8) Double Nickase Plasmid (h)

sc-400757-NIChGene KnockoutPuromycin0
(0)

Histone Deacetylase 8 (HDAC8) Double Nickase Plasmid (h2)

sc-400757-NIC-2hGene KnockoutPuromycin0
(0)

HDAC8 CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Histone Deacetylase 8 (HDAC8) CRISPR Activation Plasmid (h)

sc-400757-ACThGene ActivationPuro, Blast, Hygro0
(0)

HDAC8 siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Histone Deacetylase 8 (HDAC8) siRNA (h)

sc-35548hGene SilencingN/A
7
(0)

Histone Deacetylase 8 (HDAC8) siRNA (h2)

sc-44305hGene SilencingN/A0
(0)

Histone Deacetylase 8 (HDAC8) shRNA Plasmid (h)

sc-35548-SHhGene SilencingPuromycin
7
(0)

Histone Deacetylase 8 (HDAC8) shRNA Plasmid (h2)

sc-44305-SHhGene SilencingPuromycin0
(0)

Histone Deacetylase 8 (HDAC8) shRNA (h) Lentiviral Particles

sc-35548-VhGene SilencingPuromycin
7
(0)

Histone Deacetylase 8 (HDAC8) shRNA (h2) Lentiviral Particles

sc-44305-VhGene SilencingPuromycin0
(0)

Histone Deacetylase 8 (HDAC8) siRNA (m)

sc-35549mGene SilencingN/A
2
(0)

Histone Deacetylase 8 (HDAC8) shRNA Plasmid (m)

sc-35549-SHmGene SilencingPuromycin
2
(0)

Histone Deacetylase 8 (HDAC8) shRNA (m) Lentiviral Particles

sc-35549-VmGene SilencingPuromycin
2
(0)