COL2A1 Antibody (9F11): sc-517573
- COL2A1 Antibody (9F11) is a mouse monoclonal IgG provided at 100 µg/ml
- raised against Collagen α1 Type II of human origin
- recommended for detection of Collagen α1 Type II of mouse, rat and human origin by IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for COL2A1 Antibody (9F11). This work is in progress.
COL2A1 Antibody (9F11) is a mouse monoclonal IgG antibody that detects Collagen Type II in mouse, rat, and human samples through immunofluorescence (IF) and immunohistochemistry. Anti-COL2A1 antibody (9F11) specifically targets Collagen Type II, a crucial component of cartilage that provides structural support and resilience to joints. Collagen Type II is primarily located in the extracellular matrix of cartilage, where Collagen Type II forms a dense network of fibrils that contribute to the tissue′s mechanical properties. Collagen Type II plays a vital role in maintaining cartilage integrity and function by helping resist compressive forces and providing a scaffold for chondrocytes, the cells responsible for cartilage maintenance and repair. Disruption or degradation of Collagen Type II can lead to various joint disorders, including osteoarthritis and rheumatoid arthritis, highlighting Collagen Type II′s importance in musculoskeletal health. COL2A1 (9F11) monoclonal antibody′s ability to effectively detect Collagen Type II in different species makes COL2A1 (9F11) antibody an invaluable tool for researchers studying cartilage biology and related diseases.
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COL2A1 Antibody (9F11) References:
- Widely distributed mutations in the COL2A1 gene produce achondrogenesis type II/hypochondrogenesis. | Körkkö, J., et al. 2000. Am J Med Genet. 92: 95-100. PMID: 10797431
- Expression of two novel alternatively spliced COL2A1 isoforms during chondrocyte differentiation. | McAlinden, A., et al. 2008. Matrix Biol. 27: 254-66. PMID: 18023161
- A COL2A1 gene polymorphism is related with advanced stages of osteoarthritis of the knee in Mexican Mestizo population. | Gálvez-Rosas, A., et al. 2010. Rheumatol Int. 30: 1035-9. PMID: 19756630
- Disruption of the developmentally-regulated Col2a1 pre-mRNA alternative splicing switch in a transgenic knock-in mouse model. | Lewis, R., et al. 2012. Matrix Biol. 31: 214-26. PMID: 22248926
- Somatic mosaicism and the phenotypic expression of COL2A1 mutations. | Nagendran, S., et al. 2012. Am J Med Genet A. 158A: 1204-7. PMID: 22496037
- A mutation of the Col2a1 gene (G1170S) alters the transgenic murine phenotype and cartilage matrix homeostasis. | Yang, RC., et al. 2014. J Formos Med Assoc. 113: 803-12. PMID: 24168833
- Longitudinal Follow-Up of Two Patients with Dysspondyloenchondromatosis due to Novel Heterozygous Mutations in COL2A1. | Güneş, N., et al. 2018. Mol Syndromol. 9: 134-140. PMID: 29928178
- MicroRNA‑1 regulates the development of osteoarthritis in a Col2a1‑Cre‑ERT2/GFPfl/fl‑RFP‑miR‑1 mouse model of osteoarthritis through the downregulation of Indian hedgehog expression. | Che, X., et al. 2020. Int J Mol Med. 46: 360-370. PMID: 32626917
- Glycolytic enzyme PKM2 regulates cell senescence but not inflammation in the process of osteoarthritis. | Liu, B., et al. 2023. Acta Biochim Biophys Sin (Shanghai). 55: 1425-1433. PMID: 37525533
- Expression and localization of COL2A1 mRNA and type II collagen in human fetal cochlea. | Khetarpal, U., et al. 1994. Hear Res. 79: 59-73. PMID: 7806485
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
COL2A1 Antibody (9F11) | sc-517573 | 100 µg/ml | $322.00 |