UST Activators
UST Activators encompasses compounds that may facilitate the enzymatic activity of UST either by directly providing the necessary substrates such as PAPS or by modulating the biochemical conditions that favor the sulfotransferase's optimal function. UST requires a specific sulfonate group donor, PAPS, which is synthesized from ATP and sulfate. Chemicals that support the synthesis or availability of PAPS, like ATP and inorganic sulfate, serve as indirect activators of UST by ensuring a steady supply of this essential substrate. Furthermore, cofactors that are requisite for the enzymatic activity of UST, such as magnesium and manganese, are crucial for the enzyme's structure and function. Compounds providing these ions can be regarded as activators because they maintain the catalytic competency of UST.
Additionally, any manipulation that decreases the levels of products that inhibit sulfotransferases, can enhance UST activity. In this regard, sodium chloride and other salts may affect the enzyme's microenvironment, increasing its catalytic efficiency. Similarly, the presence of zinc and vitamins that act as cofactors for various enzymes may indirectly enhance UST's functionality.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
ATP provides the phosphate group in the formation of PAPS, which is the sulfate donor for UST. By increasing ATP levels, the synthesis of PAPS can be enhanced, thereby potentially upregulating UST activity. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $46.00 $69.00 $163.00 $245.00 $418.00 | 3 | |
Magnesium ion is a cofactor for ATP sulfurylase, the enzyme that catalyzes the first step in PAPS synthesis. Magnesium sulfate can increase the availability of magnesium, indirectly supporting UST activity by ensuring efficient PAPS production. | ||||||
Manganese(II) sulfate monohydrate | 10034-96-5 | sc-203130 sc-203130A | 100 g 500 g | $41.00 $107.00 | ||
Manganese ions act as cofactors for various enzymes, including sulfotransferases. Supplementing manganese may indirectly enhance UST activity by facilitating its catalytic action. | ||||||
Sodium Chloride | 7647-14-5 | sc-203274 sc-203274A sc-203274B sc-203274C | 500 g 2 kg 5 kg 10 kg | $19.00 $30.00 $60.00 $110.00 | 15 | |
High ionic strength conditions can influence enzyme structure and function. In some cases, sodium chloride at certain concentrations can enhance enzyme activity, potentially affecting UST as well. | ||||||
Chlorogenic Acid | 327-97-9 | sc-204683 sc-204683A | 500 mg 1 g | $47.00 $69.00 | 1 | |
Chlorogenic acid can influence various enzymatic pathways and might modulate the activity of sulfotransferases like UST through indirect mechanisms, such as altering cellular redox states. | ||||||
DHEA | 53-43-0 | sc-202573 | 10 g | $111.00 | 3 | |
While known as an inhibitor for some sulfotransferases, DHEA can also act as a substrate for others. It may modulate UST activity by competitive interaction with PAPS. | ||||||
Sodium sulfate anhydrous | 7757-82-6 | sc-212945 sc-212945A | 500 g 1 kg | $63.00 $91.00 | ||
Providing inorganic sulfate can promote the synthesis of PAPS, the sulfotransferase donor molecule, thus potentially upregulating UST activity indirectly. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is involved in metabolic pathways that generate ATP. Increased availability of NAD+ can lead to increased ATP levels, indirectly supporting UST activity. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $104.00 | ||
Pyridoxal phosphate is a cofactor for many enzymatic reactions and could influence the activity of enzymes upstream of UST, thereby affecting its overall activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc acts as a cofactor for many enzymes. Its presence is critical for the proper function of numerous proteins, and it might indirectly affect the activity of UST. | ||||||