SUN2 Activators
SUN2 Activators are a class of compounds that enhance the function of the SUN2 protein, a core component of the LINC complex that links the nucleoskeleton and cytoskeleton. They primarily work by influencing the structures and dynamics of the nuclear envelope, microtubules, and actin cytoskeleton, which SUN2 directly interacts with. Some of these activators, such as tamoxifen, affect the nuclearenvelope's structure, thereby enhancing SUN2's function. Others, like paclitaxel and nocodazole, interact with microtubules and indirectly enhance SUN2's functional activity. This is because SUN2 is involved in nuclear-cytoskeleton interactions, and changes in microtubule dynamics can have consequential effects on SUN2 function. Similarly, Cytochalasin D and Latrunculin A disrupt actin polymerization, which can also enhance SUN2 function due to its role in connecting the nuclear lamina to the actin cytoskeleton.
On the other hand, Diethylstilbestrol and Bisphenol A, synthetic compounds known for their interactions with estrogen receptors, modify the nuclear envelope structure. Since the nuclear envelope is the residence of SUN2, altering its structure can enhance the functional activity of SUN2. Lastly, compounds like Vinblastine, Vincristine, and Glyphosate disrupt microtubule formation, leading to an indirect enhancement of SUN2 function. By influencing the dynamics of the microtubules which are connected to the nucleus via SUN2, these compounds ultimately amplify the functional activity of SUN2.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $272.00 | 18 | |
Tamoxifen is a selective estrogen receptor modulator. It is known to alter the nuclear envelope's structure by influencing the distribution and function of certain proteins. This can enhance SUN2 activity by changing the environment it functions in. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel is a mitotic inhibitor used in cancer research. It can stabilize microtubules and inhibit their disassembly. Since SUN2 is involved in the anchoring of the nucleus to the cytoskeleton via microtubules, stabilizing these structures can enhance its function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule disruptor. By disrupting microtubule dynamics, it can indirectly enhance the functional activity of SUN2, as it is involved in nuclear-cytoskeleton interactions. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D is an inhibitor of actin polymerization. SUN2 is part of the LINC complex that connects the nuclear lamina to the actin cytoskeleton. Thus, alterations in actin dynamics can enhance SUN2 function. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A is a toxin that disrupts actin polymerization. Like Cytochalasin D, it can indirectly enhance SUN2 activity by altering the actin cytoskeleton that SUN2 interacts with. | ||||||
Diethylstilbestrol | 56-53-1 | sc-204720 sc-204720A sc-204720B sc-204720C sc-204720D | 1 g 5 g 25 g 50 g 100 g | $71.00 $287.00 $547.00 $1098.00 $2185.00 | 3 | |
Diethylstilbestrol is a synthetic, non-steroidal estrogen. It can alter the nuclear envelope structure, impacting SUN2's functional environment and thus enhancing its activity. | ||||||
Vinblastine Sulfate | 143-67-9 | sc-201447 sc-201447A sc-201447B sc-201447C | 10 mg 50 mg 100 mg 1 g | $109.00 $412.00 $561.00 $2244.00 | 9 | |
Vinblastine interferes with microtubule assembly. It can indirectly enhance SUN2 function by affecting nuclear-cytoskeleton interactions. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A is a synthetic compound known to interact with estrogen receptors and alter nuclear envelope structure. It can enhance SUN2 activity by changing the environment it operates in. | ||||||
Glyphosate | 1071-83-6 | sc-211568D sc-211568 sc-211568A sc-211568B sc-211568C | 250 mg 1 g 5 g 10 g 25 g | $46.00 $146.00 $416.00 $784.00 $1259.00 | 4 | |
Glyphosate is a broad-spectrum herbicide. It can affect microtubule dynamics, indirectly enhancing SUN2 function due to its role in nuclear-cytoskeleton interactions. | ||||||