SAPK4 Activators
The class of SAPK4 activators encompasses a diverse array of chemicals that stimulate the function of SAPK4, also known as c-Jun N-terminal kinase (JNK). SAPK4 plays a crucial role in cellular processes related to stress response, apoptosis, inflammation, and cellular homeostasis. The identified activators either directly target SAPK4 or act indirectly by influencing specific signaling pathways associated with SAPK4. Anisomycin, sorbitol, SP600125, UV radiation, anacardic acid, sodium arsenite, anethole dithiolethione (ADT), arsenic trioxide, beta-estradiol, rotenone, 12-O-tetradecanoylphorbol-13-acetate (TPA), and ziram represent a selection of chemicals with the ability to activate SAPK4 or its associated pathways.
Anisomycin, an antibiotic, induces SAPK4 activation by promoting the phosphorylation of c-Jun, a substrate of SAPK4. Sorbitol induces osmotic stress, leading to the activation of SAPK4 and subsequent modulation of cellular processes associated with stress response and apoptosis. SP600125, known as a selective inhibitor of SAPK4, paradoxically can activate SAPK4 at low concentrations, highlighting its dual role in modulating SAPK4 activity and influencing downstream cellular processes. Anacardic acid, sodium arsenite, ADT, arsenic trioxide, beta-estradiol, and rotenone represent diverse activators that influence SAPK4-mediated pathways associated with stress response, apoptosis, and inflammation. In summary, these chemicals contribute to a deeper understanding of SAPK4's role in normal cellular physiology. The selective modulation of SAPK4 or its associated pathways opens avenues for further investigations into the functional aspects of SAPK4 in various cellular contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is an antibiotic that activates SAPK4, also known as c-Jun N-terminal kinase (JNK). Anisomycin induces SAPK4 activation by promoting the phosphorylation of c-Jun, a substrate of SAPK4. This activation leads to the modulation of cellular processes associated with stress response, apoptosis, and inflammation. | ||||||
D-Sorbitol | 50-70-4 | sc-203278A sc-203278 | 100 g 1 kg | $29.00 $69.00 | ||
Sorbitol induces osmotic stress, leading to the activation of SAPK4. Osmotic stress triggers the SAPK4 pathway, resulting in the phosphorylation of c-Jun and the subsequent modulation of gene expression. The activation of SAPK4 by sorbitol is implicated in cellular responses to osmotic stress, influencing processes such as cell survival and apoptosis. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective inhibitor of SAPK4. Paradoxically, low concentrations of SP600125 can activate SAPK4 by promoting sustained JNK phosphorylation. This dual role makes SP600125 a unique modulator of SAPK4 activity, influencing downstream cellular processes associated with stress response, apoptosis, and inflammation. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Anacardic acid activates SAPK4 by promoting the phosphorylation of c-Jun. This activation is associated with the modulation of cellular processes such as inflammation, cell survival, and apoptosis. Anacardic acid's role in SAPK4 activation suggests its potential as a modulator of stress-related signaling pathways mediated by SAPK4. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Sodium arsenite induces oxidative stress, leading to the activation of SAPK4. The oxidative stress triggered by sodium arsenite promotes SAPK4 phosphorylation and its subsequent involvement in cellular processes associated with stress response, apoptosis, and inflammation. Sodium arsenite serves as a chemical activator providing insights into the regulatory mechanisms of SAPK4 in response to oxidative stress. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic trioxide activates SAPK4, contributing to its role in apoptosis induction and stress response. Arsenic trioxide induces SAPK4 phosphorylation, leading to the modulation of downstream targets involved in cell survival, proliferation, and apoptosis. The activation of SAPK4 by arsenic trioxide highlights its potential as a chemical activator for investigating SAPK4-mediated signaling pathways in the context of cellular stress and apoptosis. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Beta-estradiol activates SAPK4 by influencing estrogen receptor signaling. The activation of SAPK4 by beta-estradiol is implicated in cellular processes related to cell proliferation, apoptosis, and stress response. Beta-estradiol's role as a chemical activator provides insights into the crosstalk between hormone signaling and SAPK4-mediated pathways, contributing to a better understanding of SAPK4 regulation in hormone-dependent contexts. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone, a mitochondrial complex I inhibitor, activates SAPK4 as part of the cellular response to mitochondrial dysfunction. The activation of SAPK4 by rotenone is associated with the modulation of cellular processes related to oxidative stress, apoptosis, and inflammation. Rotenone's role as a chemical activator provides a tool for studying the intricate links between mitochondrial dysfunction and SAPK4-mediated signaling pathways in the context of cellular stress. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Also called Ziram, this compound activates SAPK4 by inducing cellular stress. The activation of SAPK4 by ziram is associated with the modulation of cellular processes related to stress response, apoptosis, and inflammation. Ziram's role as a chemical activator provides a valuable tool for studying the impact of environmental stressors on SAPK4-mediated signaling pathways, contributing to our understanding of the role of SAPK4 in cellular responses to environmental insults. | ||||||