PTH/PTHrP-R Activators
PTH/PTHrP-R Activators belong to a chemical class of compounds involved in the modulation of the Parathyroid Hormone/Parathyroid Hormone-Related Protein Receptor (PTH/PTHrP-R), also known as PTH1R. PTH/PTHrP-R is a G protein-coupled receptor (GPCR) primarily found in bone and kidney tissues. It plays a pivotal role in calcium homeostasis, bone remodeling, and phosphate regulation within the body. PTH and PTH-related protein (PTHrP) are the primary ligands that bind to and activate PTH/PTHrP-R. When activated, this receptor triggers intracellular signaling pathways that impact the behavior of osteoblasts, osteoclasts, and renal tubular cells, leading to changes in bone resorption, calcium reabsorption, and phosphate excretion. PTH/PTHrP-R Activators are small molecules designed to interact with PTH/PTHrP-R, influencing its activation, downstream signaling, or ligand binding properties.
The mechanism of action of PTH/PTHrP-R Activators typically involves binding to specific regions of the receptor, inducing conformational changes that can enhance or inhibit its response to endogenous ligands like PTH and PTHrP. By modulating PTH/PTHrP-R activity, these activators impact calcium and phosphate regulation, bone remodeling, and related physiological processes. Research into PTH/PTHrP-R Activators provides valuable insights into the complex regulatory mechanisms governing mineral and bone homeostasis, which are crucial for maintaining skeletal integrity and overall mineral balance.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol, a secosteroid, may enhance PTH/PTHrP-R expression by regulating calcium homeostasis and bone metabolism. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, an activator of adenylate cyclase, could potentially increase PTH/PTHrP-R expression by elevating intracellular cAMP levels. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid, a metabolite of Vitamin A, might modulate PTH/PTHrP-R expression through its role in cell differentiation and growth. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
β-Estradiol, a form of estrogen, may influence PTH/PTHrP-R expression related to bone density and calcium metabolism. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Carbonate, often used in psychiatric medicine, might affect PTH/PTHrP-R expression by altering intracellular signaling pathways. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Progesterone, a steroid hormone, could potentially modulate PTH/PTHrP-R expression related to bone metabolism and turnover. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
Calcitriol, the active form of Vitamin D, might play a role in enhancing PTH/PTHrP-R expression, closely linked with calcium and phosphate regulation. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
Adenosine 3',5'-cyclic monophosphate, a second messenger, could potentially elevate PTH/PTHrP-R expression through its role in intracellular signaling. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a synthetic glucocorticoid, might affect PTH/PTHrP-R expression in the context of inflammation and bone metabolism. | ||||||