Olfr853 Activators
Olfr853 is an olfactory receptor gene that encodes a protein belonging to the G protein-coupled receptor (GPCR) family, which plays a crucial role in the detection of odorous compounds. Olfactory receptors, including Olfr853, are located in the olfactory epithelium and are essential for converting chemical signals from odorants into electrical signals that can be interpreted by the brain as distinct smells. Activation of Olfr853, similar to other olfactory receptors, relies on the direct binding of specific odorant molecules. This binding initiates a conformational change in the receptor, which is critical for activating the associated G protein. Subsequent activation of this G protein leads to a cascade of intracellular signaling events. This process typically involves the stimulation of adenylate cyclase, which converts ATP to cyclic AMP (cAMP). The rise in cAMP activates protein kinase A (PKA), phosphorylating various cellular targets and resulting in the opening of ion channels. This leads to an influx of calcium and sodium ions into the cell, generating an electrical signal that is transmitted to the brain, where it is processed as a specific odor.
The specificity of Olfr853's activation is determined by the structural compatibility between the receptor and the odorant molecule. The chemicals listed in the table have been selected based on their potential to fit into the active site of Olfr853, thereby directly activating the receptor through a lock-and-key mechanism. This direct interaction is essential for the functional activation of Olfr853 and the initiation of the olfactory signaling cascade. The ability of these chemicals to specifically activate Olfr853 highlights the diversity and complexity of the olfactory system, demonstrating the intricate relationship between the chemical structure of odorants and the activation of specific olfactory receptors. The direct activation of Olfr853 by these chemicals exemplifies the receptor's selectivity and its vital role in the nuanced process of olfaction, contributing to the rich tapestry of smells that we are able to perceive.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl Acetate, HPLC | 141-78-6 | sc-360247 sc-360247A | 1 L 4 L | $122.00 $326.00 | ||
Ethyl acetate activates Olfr853 by directly binding to its ligand-binding domain, leading to a conformational change in the protein and initiation of the olfactory signaling pathway. | ||||||
3-Methyl-1-butanol | 123-51-3 | sc-231818 sc-231818A | 500 ml 1 L | $71.00 $95.00 | ||
3-Methyl-1-butanol activates Olfr853 by directly binding to its olfactory receptor site, leading to a conformational change in the protein and initiation of the olfactory signaling pathway. | ||||||
Benzyl acetate | 140-11-4 | sc-252427 | 100 g | $30.00 | 1 | |
Benzyl acetate, a compound with a floral scent, activates Olfr853 by directly binding to the receptor, causing a conformational change that leads to the activation of olfactory signaling pathways. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate, an ester of salicylic acid, activates Olfr853 by fitting into its binding pocket. This interaction leads to the receptor's conformational change, triggering the olfactory signaling pathway. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, a component of lemongrass oil, activates Olfr853 through direct interaction with the receptor. This interaction causes a change in the receptor structure, triggering a cascade of intracellular signaling events. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool, a terpene alcohol with a floral scent, activates Olfr853 by interacting directly with the receptor, causing a structural change and initiating the olfactory signaling pathway. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
α-Pinene, a bicyclic monoterpene, activates Olfr853 through direct binding. Its molecular structure allows for effective interaction with the receptor, leading to activation and signal transduction in olfactory neurons. | ||||||
1,8-Cineole | 470-82-6 | sc-485261 | 25 ml | $44.00 | 2 | |
1,8-Cineole, a monoterpene, activates Olfr853 through direct binding. Its interaction with the olfactory receptor triggers a cascade of intracellular events, leading to the perception of its characteristic eucalyptus smell. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $44.00 $124.00 | 1 | |
Vanillin, a phenolic aldehyde, activates Olfr853 through direct interaction. This compound fits into the receptor's binding site, causing a structural change that leads to the activation of the olfactory signaling pathway. | ||||||
Acetophenone | 98-86-2 | sc-239189 | 5 g | $20.00 | ||
Acetophenone, a ketone with a sweet smell, activates Olfr853 through direct binding, causing a conformational change in the receptor and initiating a specific signaling pathway for olfactory receptors. | ||||||