Leiomodin 3 Activators
Leiomodin 3 (LMOD3) is a protein encoded by the LMOD3 gene, predominantly expressed in cardiac and skeletal muscles. It belongs to the leiomodin family, which also includes LMOD1 and LMOD2, characterized by their actin filament nucleation activity, meaning they can initiate the formation of new actin filaments. LMOD3 is structurally similar to tropomodulins, proteins that cap the pointed ends of actin filaments, but unlike tropomodulins, LMOD3 also possesses an actin-nucleating function crucial for muscle contraction.
In muscle cells, LMOD3 plays a vital role in sarcomere organization. Sarcomeres are the fundamental contractile units of muscle fibers, and the proper assembly of these units is essential for muscle function. LMOD3 interacts with actin and other sarcomeric proteins to regulate the length and organization of thin filaments within the sarcomere.Mutations in the LMOD3 gene can lead to severe muscle disorders, such as congenital myopathies, which manifest as muscle weakness from birth. Studies of these mutations help illuminate LMOD3's role in muscle development and maintenance.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
May increase LMOD3 expression by elevating cAMP levels, which can lead to changes in muscle cell function and gene expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Could regulate LMOD3 expression through its role in cellular differentiation, including muscle cells. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Glucocorticoids can affect muscle protein synthesis and might influence LMOD3 expression in muscle tissues. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
May affect LMOD3 expression through antioxidant mechanisms and modulation of signaling pathways in muscle cells. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
As a SIRT1 activator, resveratrol might influence muscle fiber type conversion and potentially LMOD3 expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Hormonal regulation by estrogen may have effects on muscle tissue gene expression, including LMOD3. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $41.00 $77.00 $153.00 | ||
Thyroid hormones can influence muscle metabolism and might modulate LMOD3 expression. | ||||||