HOOK2 Activators
Hook microtubule-tethering protein 2 (HOOK2) is a crucial component of the cellular machinery, playing a significant role in the organization and function of the cytoskeleton. It belongs to the HOOK family of proteins, which are characterized by their involvement in microtubule-based processes and organelle positioning within cells.The primary function of HOOK2 is to mediate the positioning and tethering of organelles, particularly the centrosome and the Golgi apparatus. This is essential for maintaining proper cellular architecture and for ensuring accurate organelle distribution during cell division. HOOK2 achieves this by interacting with microtubules, the structural components of the cytoskeleton that facilitate transport within the cell and are integral to cell shape and division.
Structurally, HOOK2 is distinguished by the presence of a coiled-coil domain, which is typical of the HOOK protein family and is key to its function in organelle tethering. This domain facilitates the interaction of HOOK2 with other proteins and microtubules, enabling it to anchor organelles in specific cellular locations.Alterations in HOOK2 function or expression can have significant implications for cellular organization and function. Given its role in organelle positioning, changes in HOOK2 activity can disrupt cellular processes such as intracellular transport, cell signaling, and cell division. This makes HOOK2 a protein of interest in studies of cell biology and various diseases where cytoskeletal dysregulation is a factor.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
As a microtubule-stabilizing agent, paclitaxel might influence HOOK2 expression by affecting microtubule dynamics. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
A microtubule-depolymerizing agent, nocodazole could affect HOOK2 expression by altering microtubule organization. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
By elevating cAMP levels, forskolin could potentially modulate HOOK2 expression through various signaling pathways. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
As an inducer of oxidative stress, hydrogen peroxide might influence HOOK2 expression as part of the cellular stress response. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Involved in cell differentiation, retinoic acid might modulate HOOK2 expression in developing cells. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
A glucocorticoid, dexamethasone could affect HOOK2 expression as part of the stress and immune response. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium can affect various signaling pathways, potentially influencing HOOK2 expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
As an mTOR inhibitor, rapamycin might affect HOOK2 expression in relation to cell growth and metabolism. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
A stress-inducing agent that disrupts calcium homeostasis, thapsigargin could influence HOOK2 expression. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Another microtubule-targeting agent, vinblastine could affect HOOK2 expression by disrupting microtubule dynamics. | ||||||