FLRG Activators
FLRG activators are largely characterized by their influence on the TGF-β signaling pathway and the activins, given the protein's role in binding these ligands. SB431542, LDN-193189, A8301, DMH1, LY364947, Thiazovivin, RepSox, EW-7197, Galunisertib, and SD-208 represent a class of molecules that primarily target ALK receptors or other components of the TGF-β signaling cascade. Their ability to modulate this pathway can, in turn, shape the demands on FLRG as a binding protein. Specifically, the modulation of ALK4, ALK5, and ALK7 receptors can indirectly emphasize or diminish the importance of FLRG in balancing the actions of ligands like activins. Forskolin, on the other hand, provides a broader cellular impact by elevating cAMP levels, influencing a plethora of cellular events and pathways that may intersect with FLRG's roles.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
A potent inhibitor of BMP type I receptors (ALK2 and ALK3); its modulation of BMP signaling can indirectly affect FLRG. | ||||||
DMH-1 | 1206711-16-1 | sc-361171 sc-361171B sc-361171A sc-361171C | 10 mg 25 mg 50 mg 100 mg | $213.00 $318.00 $632.00 $1047.00 | 2 | |
A BMP receptor inhibitor; its impact on BMP signaling could potentially affect FLRG functions indirectly. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates cAMP levels and can influence numerous cellular pathways, potentially having indirect effects on FLRG. | ||||||
Thiazovivin | 1226056-71-8 | sc-361380 sc-361380A | 10 mg 25 mg | $284.00 $634.00 | 15 | |
Targets ALK5; its modulation of TGF-β signaling can indirectly influence FLRG's role in the pathway. | ||||||
EW-7197 | 1352608-82-2 | sc-507465 | 5 mg | $345.00 | ||
A selective ALK5 inhibitor; by affecting TGF-β signaling, it can have an indirect influence on FLRG. | ||||||