FKBP11 Activators
FKBP11 activators are compounds that specifically interact with and modulate the function of the protein FKBP11, which is a member of the FK506 binding protein (FKBP) family. This family is characterized by its members' ability to bind immunophilins, which are proteins that have the capacity to bind to immunosuppressive drugs such as FK506 (tacrolimus). FKBP11 shares structural similarities with other members of the FKBP family, including the presence of a peptidyl-prolyl isomerase (PPIase) domain, which allows these proteins to assist in protein folding by catalyzing the cis-trans isomerization of proline imidic peptide bonds in polypeptide chains. However, the specific functions and binding partners of FKBP11 can differ from those of other FKBPs, making the activators of FKBP11 unique in their selectivity and mode of action.
The development of FKBP11 activators involves the understanding of the protein's structure and the mechanisms by which it interacts with other cellular components. These activators are usually small molecules that can bind to the active site or another strategic location on the FKBP11 protein, altering its conformation and modulating its activity. The precise modulation might result in a change in the protein's interaction with other cellular machinery or influence its PPIase activity. The discovery and characterization of these activators require sophisticated techniques such as high-throughput screening, computational modeling, and structure-activity relationship (SAR) studies to identify compounds that have the desired effect on the protein. Since FKBP11 is involved in complex cellular processes, the specific alterations in its activity due to the binding of activators can influence various aspects of its role within the cell, ranging from protein folding to interactions with other cellular proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A binds to the immunophilin FKBP12. However, due to the similarity in the immunophilin domain, it can enhance FKBP11 by preventing its natural inhibitory interaction with calcineurin, thus indirectly upregulating calcineurin activity which is involved in T-cell activation and could enhance FKBP11’s role in immunoregulatory processes. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG is an Hsp90 inhibitor that can lead to the increased expression of co-chaperones, including immunophilins like FKBP11. By inhibiting Hsp90, it could indirectly enhance the stabilizing role of FKBP11 in protein complexes and increase its functional activity related to protein folding and stress response. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin also targets Hsp90, potentially increasing the expression and activity of co-chaperones such as FKBP11. This can enhance FKBP11’s chaperone activity, assisting in the proper folding of proteins and maintaining cellular homeostasis. | ||||||
Radicicol | 12772-57-5 | sc-200620 sc-200620A | 1 mg 5 mg | $92.00 $333.00 | 13 | |
Radicicol binds to Hsp90, and its inhibition can increase co-chaperone activity, including that of FKBP11. By inhibiting Hsp90, FKBP11’s role in chaperoning and protein complex stabilization could be enhanced, thereby increasing its activity in the cellular stress response. | ||||||
Pifithrin-α hydrobromide | 63208-82-2 | sc-45050 sc-45050A | 5 mg 25 mg | $120.00 $300.00 | 36 | |
Pifithrin-α(HBr) is an inhibitor of p53 binding to mitochondria, which can increase the demand for molecular chaperones during cellular stress, potentially enhancing the activity of FKBP11 as it may assist in the folding and stability of p53 and other stress-related proteins. | ||||||
NVP-AUY922 | 747412-49-3 | sc-364551 sc-364551A sc-364551B sc-364551C sc-364551D sc-364551E | 5 mg 25 mg 100 mg 250 mg 1 g 5 g | $150.00 $263.00 $726.00 $1400.00 $2900.00 $11000.00 | 3 | |
NVP-AUY922 is an inhibitor of Hsp90, and by inhibiting this chaperone, it can indirectly enhance the activity of FKBP11 through increased demand for its chaperone functions in the folding of client proteins and managing the stress response. | ||||||
BIIB 021 | 848695-25-0 | sc-364434 sc-364434A | 5 mg 25 mg | $128.00 $650.00 | ||
BIIB021 is an oral Hsp90 inhibitor that can lead to an upregulation of co-chaperones, including FKBP11. By inhibiting Hsp90 and thus increasing the functional requirement for FKBP11 in protein folding and complex assembly, BIIB021 can enhance FKBP11's activity. | ||||||