FKBP11 Antibody (D-3): sc-398700
- FKBP11 Antibody (D-3) is a mouse monoclonal IgG3 κ FKBP11 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 65-91 within an internal region of FKBP11 of human origin
- FKBP11 Antibody (D-3) is recommended for detection of FKBP11 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-FKBP11 Antibody (D-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG3 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FKBP11 Antibody (D-3) for WB applications. These reagents are now offered in bundles with FKBP11 Antibody (D-3) (see ordering information below).
FKBP11 Antibody (D-3) is a mouse monoclonal IgG3 kappa light chain antibody that detects FKBP11 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FKBP11 (D-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FKBP11, also known as FK506-binding protein 11 or FKBP19, is a 201 amino acid single-pass membrane protein that plays a crucial role in the folding and trafficking of proteins within the endoplasmic reticulum, which is essential for maintaining cellular homeostasis and function. FKBP11 belongs to the FKBP-type peptidyl-prolyl isomerase family, which catalyzes the folding of proline-rich polypeptides, thereby influencing various cellular processes. FKBP11 is predominantly expressed in secretory tissues such as the pancreas, pituitary gland, stomach, lymph nodes, and salivary glands, and is encoded by a gene located on human chromosome 12q13.12. Notably, FKBP11 activity can be inhibited by immunosuppressive drugs like FK506 and rapamycin, which highlights its significance in pharmacological contexts and potential therapeutic applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FKBP11 Antibody (D-3) References:
- Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts. | Göthel, SF. and Marahiel, MA. 1999. Cell Mol Life Sci. 55: 423-36. PMID: 10228556
- Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family. | Patterson, CE., et al. 2002. Genomics. 79: 881-9. PMID: 12036304
- The involvement of mammalian and plant FK506-binding proteins (FKBPs) in development. | Breiman, A. and Camus, I. 2002. Transgenic Res. 11: 321-35. PMID: 12212836
- Peptidylprolyl cis/trans isomerases (immunophilins): biological diversity--targets--functions. | Galat, A. 2003. Curr Top Med Chem. 3: 1315-47. PMID: 12871165
- The human FK506-binding proteins: characterization of human FKBP19. | Rulten, SL., et al. 2006. Mamm Genome. 17: 322-31. PMID: 16596453
- FKBP family proteins: immunophilins with versatile biological functions. | Kang, CB., et al. 2008. Neurosignals. 16: 318-25. PMID: 18635947
- Peptidylproline cis-trans-isomerases: immunophilins. | Galat, A. 1993. Eur J Biochem. 216: 689-707. PMID: 8404888
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FKBP11 Antibody (D-3) | sc-398700 | 200 µg/ml | $322.00 | |||
FKBP11 Antibody (D-3): m-IgGκ BP-HRP Bundle | sc-524452 | 200 µg Ab, 40 µg BP | $361.00 | |||
FKBP11 Antibody (D-3): m-IgG3 BP-HRP Bundle | sc-552106 | 200 µg Ab; 40 µg BP | $361.00 | |||
FKBP11 Antibody (D-3) AC | sc-398700 AC | 500 µg/ml, 25% agarose | $424.00 | |||
FKBP11 Antibody (D-3) HRP | sc-398700 HRP | 200 µg/ml | $322.00 | |||
FKBP11 Antibody (D-3) FITC | sc-398700 FITC | 200 µg/ml | $336.00 | |||
FKBP11 Antibody (D-3) PE | sc-398700 PE | 200 µg/ml | $349.00 | |||
FKBP11 Antibody (D-3) Alexa Fluor® 488 | sc-398700 AF488 | 200 µg/ml | $364.00 | |||
FKBP11 Antibody (D-3) Alexa Fluor® 546 | sc-398700 AF546 | 200 µg/ml | $364.00 | |||
FKBP11 Antibody (D-3) Alexa Fluor® 594 | sc-398700 AF594 | 200 µg/ml | $364.00 | |||
FKBP11 Antibody (D-3) Alexa Fluor® 647 | sc-398700 AF647 | 200 µg/ml | $364.00 | |||
FKBP11 Antibody (D-3) Alexa Fluor® 680 | sc-398700 AF680 | 200 µg/ml | $364.00 | |||
FKBP11 Antibody (D-3) Alexa Fluor® 790 | sc-398700 AF790 | 200 µg/ml | $364.00 | |||
FKBP11 (D-3) Neutralizing Peptide | sc-398700 P | 100 µg/0.5 ml | $69.00 |