FAM117A Activators
The chemical class HROB Activators comprises agents that influence cellular pathways which either directly or indirectly lead to the upregulation of HROB. These chemicals generally create environments in which the necessity for DNA repair or stabilization is increased, thereby requiring the enhanced activity of HROB. Caffeine and Sodium Orthovanadate, for example, enhance ATR and PI3K activity respectively, both pathways being involved in DNA repair. An active ATR and PI3K pathway will likely necessitate a functional HROB protein for effective DNA repair or stabilization.
Other chemicals like Taurine and U0126 function by providing protective effects against DNA damage or by enhancing cellular signaling that leads to the recruitment of DNA repair proteins like HROB. Taurine, an antioxidant, can upregulate repair pathways, thus requiring HROB for effective function. U0126 enhances ERK signaling, which may involve pathways that necessitate the activity of HROB for DNA repair. These chemicals do not directly activate HROB but create conditions where its activity is essential for cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Enhances ATR activity, promoting DNA damage repair and requiring HROB for effective function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Enhances DNA-binding activity, thus may facilitate the function of HROB in DNA repair processes. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Activates the phosphatidylinositol 3-kinase (PI3K) pathway, which is involved in DNA repair, potentially involving HROB. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Increases DNA-PK activity, potentially boosting the DNA repair mechanisms that engage HROB. | ||||||
Taurine | 107-35-7 | sc-202354 sc-202354A | 25 g 500 g | $48.00 $102.00 | 1 | |
Antioxidant that protects against DNA damage; its presence can upregulate repair pathways where HROB is involved. | ||||||
Sodium selenite | 10102-18-8 | sc-253595 sc-253595B sc-253595C sc-253595A | 5 g 500 g 1 kg 100 g | $49.00 $183.00 $316.00 $98.00 | 3 | |
Induces oxidative stress, resulting in a cellular environment that necessitates HROB activation for DNA repair. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Activates glucocorticoid receptors that can engage in DNA repair, potentially involving HROB. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Activates pathways involving tyrosine kinases, which can require HROB for DNA repair. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Stimulates pathways involved in oxidative stress repair, potentially requiring HROB. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Induces mild DNA damage, creating a condition where the cell may require HROB for repair mechanisms. | ||||||