ERp19 Activators
ERp19 Activators are a class of compounds that enhance the functional activity of ERp19, a protein disulfide isomerase (PDI) involved in the formation and breakage of disulfide bonds during protein folding. Many of these activators are reducing agents such as Dithiothreitol (DTT), 2-Mercaptoethanol, Beta-Mercaptoethanol, TCEP, Glutathione (GSH), and Ascorbic Acid. These compounds can reduce disulfide bonds in proteins, an essential step in the process of PDI activity. As ERp19 is a member of the PDI family, the action of these reducing agents enhances its functional activity. Reducing agents provide the necessary electrons for the reduction of disulfide bonds, facilitating the protein folding process that ERp19 is involved in.
Other ERp19 activators work by enhancing the cell's overall redox state or providing cofactors for enzymes involved in disulfide bond reduction. Sodium Selenite and Selenocysteine, for example, are sources of selenium, a vital cofactor for the enzyme thioredoxin reductase which regenerates reduced thioredoxin from oxidized thioredoxin. This indirectly enhances the PDI activity of ERp19. NADPH and Lipoic Acid also serve as cofactors, providing reducing equivalents for PDI activity. Melatonin induces the expression of thioredoxin reductase, thereby indirectly enhancing ERp19's PDIactivity. Lastly, Alpha-Tocopherol (Vitamin E), a lipid-soluble antioxidant, can protect the redox state of the cell, indirectly enhancing the PDI activity of ERp19.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Mercaptoethanol | 60-24-2 | sc-202966A sc-202966 | 100 ml 250 ml | $90.00 $120.00 | 10 | |
2-Mercaptoethanol is a reducing agent that, like DTT, can enhance the PDI activity of ERp19. It also reduces disulfide bonds in proteins, which is an essential step in the process of PDI activity. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $82.00 $2091.00 | 8 | |
GSH is a reducing agent that can enhance the PDI activity of ERp19. It can reduce disulfide bonds in substrates, facilitating the PDI activity. | ||||||
Sodium selenite | 10102-18-8 | sc-253595 sc-253595B sc-253595C sc-253595A | 5 g 500 g 1 kg 100 g | $49.00 $183.00 $316.00 $98.00 | 3 | |
Sodium Selenite is a source of selenium which is a cofactor for thioredoxin reductase, an enzyme that regenerates reduced thioredoxin from oxidized thioredoxin. This can indirectly enhance the PDI activity of ERp19. | ||||||
β-Nicotinamide adenine dinucleotide phosphate | 53-59-8 | sc-215560 sc-215560A | 100 mg 250 mg | $182.00 $319.00 | ||
NADPH provides the reducing equivalents for PDI activity, acting as a cofactor in the reduction of disulfide bonds, which can enhance the PDI activity of ERp19. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic Acid is a reducing agent that can enhance the PDI activity of ERp19. It can reduce disulfide bonds in substrates, facilitating the PDI activity. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Lipoic Acid is a cofactor for several dehydrogenases and can enhance the PDI activity of ERp19 by reducing disulfide bonds in substrates. | ||||||
Melatonin | 73-31-4 | sc-207848 sc-207848A sc-207848B sc-207848C sc-207848D sc-207848E | 1 g 5 g 25 g 100 g 250 g 1 kg | $65.00 $73.00 $218.00 $697.00 $1196.00 $3574.00 | 16 | |
Melatonin can induce the expression of thioredoxin reductase which can indirectly enhance the PDI activity of ERp19. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B sc-214454C | 10 g 25 g 100 g 1 kg | $43.00 $62.00 $141.00 $430.00 | ||
Alpha-Tocopherol is a lipid-soluble antioxidant that can protect the redox state of the cell, thereby indirectly enhancing the PDI activity of ERp19. | ||||||