ERp19 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Iodoacetamide | 144-48-9 | sc-203320 | 25 g | $255.00 | 1 | |
Iodoacetamide can react with cysteine residues in proteins, leading to the alkylation of thiol groups. ERp19 has a catalytic domain with cysteine residues critical for its enzymatic function, and alkylation of these residues by iodoacetamide would inhibit its protein disulfide isomerase activity. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $33.00 $136.00 $458.00 | 5 | |
Ebselen is a seleno-organic compound that can mimic glutathione peroxidase activity and also covalently modify thiol groups in proteins. By modifying the thiol groups of cysteine residues in ERp19, ebselen can inhibit its enzymatic activity. | ||||||
Bacitracin | 1405-87-4 | sc-252399 | 5 g | $89.00 | 1 | |
Bacitracin is known to inhibit protein disulfide isomerase enzymes by binding to their active sites. As ERp19 exhibits protein disulfide isomerase-like activity, bacitracin can directly inhibit this activity, thereby functionally inhibiting ERp19. | ||||||
Phenylarsine oxide | 637-03-6 | sc-3521 | 250 mg | $41.00 | 4 | |
Phenylarsine oxide can bind to vicinal thiol groups in proteins, inhibiting protein disulfide isomerase enzymes by crosslinking the cysteine residues. This mechanism can inhibit the enzymatic activity of ERp19. | ||||||
Aurintricarboxylic Acid | 4431-00-9 | sc-3525 sc-3525A sc-3525B sc-3525C | 100 mg 1 g 5 g 10 g | $20.00 $32.00 $48.00 $94.00 | 13 | |
Aurintricarboxylic acid is a polyaromatic carboxylic acid known to inhibit various protein-nucleic acid interactions. It can inhibit the enzymatic function of ERp19 by nonspecifically associating with its catalytic domain, obstructing substrate access. | ||||||
Ethacrynic acid | 58-54-8 | sc-257424 sc-257424A | 1 g 5 g | $90.00 $300.00 | 5 | |
Ethacrynic acid contains a reactive α,β-unsaturated ketone that can form adducts with cysteine residues. By modifying the active site cysteines in ERp19, ethacrynic acid can inhibit its enzymatic function. | ||||||
Diethylmaleate | 141-05-9 | sc-202577 | 5 g | $27.00 | 4 | |
Diethyl maleate is an alkylating agent that can conjugate to the thiol groups of cysteine residues. This can inhibit ERp19 by blocking the cysteine residues essential for its disulfide isomerase activity. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation. ERp19 has been implicated in the quality control of glycoprotein folding. Inhibition of glycosylation can indirectly affect the substrate availability and function of ERp19. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties that can modulate the redox state of cells. By altering the redox environment, quercetin can indirectly affect the disulfide bond formation and isomerase activity of ERp19. | ||||||