ECEL1 Activators
ECEL1 activators typically function by stimulating the production and release of endothelins, which serve as substrates for ECEL1. The more available the endothelins, the more ECEL1 can process these and increase its peptidase activity. This is usually achieved by these compounds either directly influencing endothelin production or indirectly affecting cellular signaling pathways that lead to endothelin production.
For instance, several neurotransmitters (Acetylcholine, Norepinephrine) and hormones (Angiotensin II, Urocortin) are known to stimulate endothelin production. Chemicals like ATP, linked with energy transfer and signaling, can also enhance endothelin production. Other compounds, such as Forskolin and Thapsigargin, influence cellular signaling pathways involving cyclic AMP and intracellular calcium, respectively, which can result in increased endothelin availability. Furthermore, certain compounds (PMA, Anisomycin) activate specific kinases known to upregulate endothelin production.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
Norepinephrine is a neurotransmitter and hormone. Similar to Acetylcholine, it can stimulate the production and release of endothelins, providing more substrate for ECEL1, and indirectly increasing its activity. | ||||||
ATP | 56-65-5 | sc-507511 | 5 g | $17.00 | ||
ATP is a primary intracellular energy source, but it also functions as a signaling molecule. ATP can stimulate the production of endothelins, indirectly affecting the activity of ECEL1. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Angiotensin II is a peptide hormone that can stimulate endothelin production. Increased levels of endothelin would provide more substrate for ECEL1, potentially leading to increased activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a compound known to activate Protein Kinase C (PKC), which can increase the production of endothelins, providing more substrate for ECEL1 and indirectly increasing its activity. | ||||||
Calcium | 7440-70-2 | sc-252536 | 5 g | $209.00 | ||
Calcium ions are fundamental in cell signaling. They can stimulate the production and release of endothelins, providing more substrate for ECEL1. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a labdane diterpenoid found in the Indian Coleus plant. It is known to raise levels of cyclic AMP, which can stimulate endothelin production, indirectly affecting ECEL1 activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a sesquiterpene lactone, known to increase intracellular calcium concentration. This elevated calcium can stimulate the production of endothelins, indirectly affecting ECEL1. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is an antibiotic that can activate c-Jun N-terminal kinases (JNK), which can subsequently increase the production of endothelins, providing more substrate for ECEL1. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $104.00 $431.00 | ||
EPA is an omega-3 fatty acid. It can enhance the production of endothelins, which ECEL1 can process, indirectly influencing its activity. | ||||||