5330417C22Rik Activators
Chemical activators of endosome-lysosome associated apoptosis and autophagy regulator 1 play diverse roles in its activation through various cellular pathways. Rapamycin, by binding to FKBP12, inhibits the mTOR pathway, a pivotal controller of autophagy, thus facilitating the activation of endosome-lysosome associated apoptosis and autophagy regulator 1. Similarly, spermidine promotes the activation of this regulator by hindering the acetyltransferase EP300, which enables the transcription of autophagy-related genes. Lithium, through the inhibition of inositol monophosphatase, causes an inositol shortage and interrupts the IP3 signaling, thereby triggering autophagy and consequently activating the regulator. Carbamazepine follows a different route by inhibiting voltage-gated sodium channels, which indirectly stimulates the autophagic machinery, leading to the activation of the endosome-lysosome associated apoptosis and autophagy regulator 1.
Furthermore, valproic acid, by inhibiting histone deacetylase, leads to the hyperacetylation of proteins and subsequent activation of autophagic pathways, affecting endosome-lysosome associated apoptosis and autophagy regulator 1. Resveratrol exerts its effect through the SIRT1-dependent pathway that promotes autophagy, thereby influencing the activity of the regulator. Trehalose, an mTOR-independent autophagy activator, enhances protein aggregate clearance via autophagy, which may activate the regulator. Verapamil and felodipine both modulate autophagy by altering calcium signaling, due to their calcium channel blocking properties, thus impacting the functionality of endosome-lysosome associated apoptosis and autophagy regulator 1. Metformin, through the activation of AMPK in response to low cellular energy levels, initiates autophagy, which has implications for the activity of this regulator. Chloroquine, by inhibiting lysosomal acidification, prevents autophagosome-lysosome fusion, a process that can activate the regulator. Lastly, minocycline's activation of autophagy, possibly via mTOR pathway inhibition, can also lead to the activation of endosome-lysosome associated apoptosis and autophagy regulator 1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin specifically binds to FKBP12 and the complex inhibits the mTOR pathway, which is a critical regulator of autophagy. This inhibition can lead to the activation of endosome-lysosome associated apoptosis and autophagy regulator 1, as it is a protein that plays a role in autophagy. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine is known to induce autophagy by inhibiting the acetyltransferase EP300, which leads to the activation of autophagy-related genes. As endosome-lysosome associated apoptosis and autophagy regulator 1 is involved in the autophagic process, spermidine therefore facilitates its activation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium activates the autophagy pathway by inhibiting inositol monophosphatase, leading to the depletion of inositol and inhibition of the IP3 signal, which can activate endosome-lysosome associated apoptosis and autophagy regulator 1 as a result of induced autophagy. | ||||||
Carbamazepine | 298-46-4 | sc-202518 sc-202518A | 1 g 5 g | $33.00 $71.00 | 5 | |
Carbamazepine activates autophagy by inhibiting the activity of voltage-gated sodium channels, which can lead to the activation of endosome-lysosome associated apoptosis and autophagy regulator 1 through the induction of the autophagy process. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid induces autophagy by inhibiting histone deacetylase (HDAC), which can lead to hyperacetylation of proteins and activation of autophagy pathways, subsequently activating endosome-lysosome associated apoptosis and autophagy regulator 1. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can activate autophagy via the sirtuin 1 (SIRT1)-dependent pathway, which in turn can lead to the activation of endosome-lysosome associated apoptosis and autophagy regulator 1 by promoting autophagic processes. | ||||||
D-(+)-Trehalose Anhydrous | 99-20-7 | sc-294151 sc-294151A sc-294151B | 1 g 25 g 100 g | $30.00 $167.00 $260.00 | 2 | |
Trehalose acts as an mTOR-independent autophagy activator, which can enhance the clearance of aggregated proteins through autophagy, thereby potentially activating endosome-lysosome associated apoptosis and autophagy regulator 1. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil activates autophagy by blocking calcium channels, which affects the calcium homeostasis and can activate autophagy pathways, thus leading to the activation of endosome-lysosome associated apoptosis and autophagy regulator 1. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin activates AMP-activated protein kinase (AMPK), which is an energy sensor that can initiate autophagy when cellular energy is low, thereby leading to the activation of endosome-lysosome associated apoptosis and autophagy regulator 1. | ||||||
Felodipine | 72509-76-3 | sc-201483 sc-201483A | 10 mg 50 mg | $91.00 $222.00 | 1 | |
Felodipine induces autophagy by blocking calcium channels, similar to verapamil, and this modulation in calcium signaling can lead to the activation of endosome-lysosome associated apoptosis and autophagy regulator 1. | ||||||