Anticorps SIRT1 (33.36): sc-135792
- L'Anticorps SIRT1 (33.36) est un monoclonal de souris IgG1 κ, cité dans 9 publications, fourni en 200 µg/ml
- dirigé contre la SIRT1 recombinante d'origine human
- recommandé pour la détection de SIRT1 d'origine mouse, rat et human par WB, IP, IF, IHC(P) et ELISA
- Voir SIRT1 (B-7): sc-74465 pour d'autres anticorps conjugués SIRT1, dont AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 et 790.
- m-IgG1 BP-HRP et m-IgGκ BP-HRP sont les réactifs secondaires recommandés pour la détection de l'anticorps SIRT1 (33.36) pour des applications de WB and IHC(P). Ces réactifs sont maintenant proposés en kit avec l'anticorps SIRT1 (33.36) (voir Informations pour la commande ci-dessous).
The silent information regulator (SIR2) family of genes are highly-conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. In S. cerevisiae, Sir2p deacetylates histones in an NAD-dependent manner, which regulates silencing at the telomeric, rDNA and silent mating-type loci. Sir2p is the founding member of a large family, designated sirtuins, which contain a conserved catalytic domain. The human homologs, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT1 has the closest homology to the yeast Sir2p and is widely expressed in fetal and adult tissues. SIRT1 is highly expressed in heart, brain and skeletal muscle, with low expression in lung and placenta. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically at Lys 382.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps SIRT1 (33.36) | sc-135792 | 200 µg/ml | $316.00 | |||
SIRT1 (33.36): m-IgGκ BP-HRP Kit | sc-534620 | 200 µg Ab; 40 µg BP | $354.00 | |||
SIRT1 (33.36): m-IgG1 BP-HRP Kit | sc-538870 | 200 µg Ab; 20 µg BP | $354.00 |