caspase-3 Antibody (3F49): sc-70498

caspase-3 Antibody (3F49) is a mouse monoclonal IgG2a kappa light chain antibody engineered to detect both active caspase-3 and its inactive precursor, procaspase-3, across mouse, rat, and human species. Caspase-3, also known as apopain, SCA-1, Yama, and CPP32, is a pivotal aspartate-specific cysteine protease within the ICE subfamily, playing a central role in the execution phase of apoptosis. Caspase-3 interacts with several key molecules, including PARP, which caspase-3 cleaves to facilitate the dismantling of cellular components, and other caspases such as caspase-6, -7, and -9, thereby amplifying the apoptotic signal. Additionally, caspase-3 interacts with proteins involved in the regulation of apoptosis, such as Bcl-2 and XIAP, which modulate caspase-3 activity and ensure the proper progression of programmed cell death. The ability of caspase-3 to engage with these interacting proteins is crucial for maintaining cellular homeostasis and preventing the development of diseases like cancer and neurodegenerative disorders. Anti-caspase-3 antibody (3F49) is indispensable for researchers studying these interactions, offering reliable performance in applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-caspase-3 antibody (3F49) is an essential tool for elucidating the complex network of protein interactions that govern apoptosis and related cellular processes. Whether investigating the mechanisms of cell death or the interplay between apoptotic regulators, caspase-3 monoclonal antibody (3F49) provides the accuracy and reliability needed for advanced biomedical research.

The preferred caspase-3 antibody is caspase-3 Antibody (E-8): sc-7272.