Gpa2 Inhibitors
Gpa2 inhibitors encompass a diverse range of compounds designed to indirectly modulate the function or signaling pathways associated with Gpa2. Given that Gpa2 is a G protein-coupled receptor, many of these inhibitors target G protein-related pathways, either upstream or downstream, to influence its function. Pertussis toxin, for example, can ADP-ribosylate certain G-proteins, disrupting their function and subsequently the pathways they regulate.
Similarly, compounds like NF449, YM-254890, focus on different subsets of G-proteins, asserting their effects by either directly inhibiting these proteins or antagonizing their function. On the downstream end, agents like U73122 and KT5720 inhibit effectors like phospholipase C and protein kinase A, respectively, both of which are involved in G protein signaling cascades.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Known to ADP-ribosylate and inactivate certain G-proteins. This can inhibit Gpa2 indirectly by altering G-protein coupled receptor signaling. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $203.00 $469.00 $1509.00 | 1 | |
Acts as a potent Gsα-selective G protein antagonist which can interfere with Gpa2-associated pathways. | ||||||
YM 254890 | 568580-02-9 | sc-507356 | 1 mg | $510.00 | ||
Inhibits Gq-type G-protein signaling which might affect pathways associated with Gpa2. | ||||||
Gallein | 2103-64-2 | sc-202631 | 50 mg | $85.00 | 20 | |
Binds to Gβγ subunits, affecting G protein-coupled receptor signaling pathways that might be associated with Gpa2. | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $138.00 $220.00 $972.00 | 47 | |
PKA inhibitor. Since G proteins can activate adenylate cyclase leading to PKA activation, inhibiting PKA can modulate Gpa2 function. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
A CDC42 inhibitor which can modulate downstream signaling from various G-proteins, potentially influencing pathways related to Gpa2. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Inhibits ROCK which is downstream of some G-protein signaling pathways, potentially influencing processes associated with Gpa2. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $278.00 | 6 | |
Inhibits cytohesins, affecting ARF activation and potentially modulating pathways related to or influenced by Gpa2. | ||||||
Tozasertib | 639089-54-6 | sc-358750 sc-358750A | 25 mg 50 mg | $62.00 $87.00 | 4 | |
Inhibits Aurora kinases, which can play a role in cell cycle and mitosis, potentially influencing cell processes associated with Gpa2 signaling. | ||||||