Gpa2 Activators
Gpa2 activators encompass a group of chemicals that can indirectly enhance the expression or function of glycoprotein hormone alpha-2 through their actions on various cellular signaling pathways. These activators typically exert their effects by elevating intracellular levels of cyclic AMP (cAMP), a critical second messenger in signaling pathways that modulate the synthesis of glycoprotein hormones. Increased cAMP activates protein kinase A (PKA), a pivotal kinase in the phosphorylation of transcription factors that govern the expression of hormone-related genes.
The engagement of these activators with cellular mechanisms is specific and targeted. Forskolin, by directly activating adenylate cyclase, boosts cAMP synthesis, setting in motion a cascade that culminates in gene transcription. Similarly, IBMX and Rolipram prevent the degradation of cAMP, amplifying PKA signaling. PMA activates PKC, which can also influence transcriptional regulation in a pathway parallel to that activated by cAMP.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels, which can lead to the activation of protein kinase A (PKA). PKA can phosphorylate transcription factors that enhance the transcription of genes including those involved in glycoprotein hormone synthesis. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC) which is involved in signaling cascades that regulate gene expression, potentially increasing the transcription of glycoprotein hormones including Gpa2. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
Direct activator of PKA as a second messenger, which may stimulate the transcription of glycoprotein hormone-related genes, possibly influencing Gpa2 levels. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
A synthetic catecholamine that activates adrenergic receptors leading to increased cAMP and activation of PKA, potentially enhancing Gpa2 expression. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Non-selective inhibitor of phosphodiesterases, preventing the breakdown of cAMP and thus enhancing PKA activity, which could promote Gpa2 expression. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Phosphodiesterase-4 inhibitor, increasing intracellular cAMP levels and potentially enhancing the transcription of glycoprotein hormone genes through PKA activation. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $40.00 $46.00 $100.00 | 26 | |
A nonspecific G-protein activator and phosphodiesterase inhibitor, it can lead to increased cAMP levels and activate PKA, possibly influencing Gpa2 expression. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A membrane-permeable cAMP analog that directly activates PKA, potentially increasing the transcription of genes involved in glycoprotein hormone regulation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Stimulates adenylate cyclase through adrenergic receptors, increasing cAMP levels and activating PKA, which may enhance the transcription and synthesis of glycoprotein hormones, potentially affecting Gpa2 expression. | ||||||