HSP 27 Antibody (G3.1): sc-59562
- HSP 27 Antibody (G3.1) is a mouse monoclonal IgG1, cited in 7 publications, provided at 100 µg/ml
- raised against partially purified HSP 27 derived from MCF-7 cytosol of human origin
- recommended for detection of HSP 27 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See HSP 27 (F-4): sc-13132 for HSP 27 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HSP 27 Antibody (G3.1). This work is in progress.
HSP 27 Antibody (G3.1) is a mouse monoclonal IgG1 antibody that detects HSP 27 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. HSP 27 is a crucial member of the heat shock protein family, functioning primarily as a molecular chaperone that assists in protein folding and protects cells from stress-induced damage. HSP 27 is predominantly located in the cytoplasm but translocates to the nucleus under stress conditions, highlighting its role in cellular response mechanisms. HSP 27′s ability to relocate allows for the regulation of various cellular processes, including apoptosis and cell survival, particularly in response to heat shock, cytokines, and hormonal signals. Notably, HSP 27 undergoes extensive post-translational modifications, including phosphorylation, which enhances chaperone activity and is critical for protective functions during cellular stress. HSP 27′s regulation by hormones like estrogen suggests a potential link to tumorigenesis in breast cancer, making HSP 27 a valuable target for understanding cancer biology and developing therapeutic strategies. Anti-HSP 27 antibody (G3.1) is an essential tool for researchers investigating this protein′s role in various physiological and pathological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HSP 27 Antibody (G3.1) References:
- HSP 27 as possible prognostic factor in patients with oral squamous cell carcinoma. | Lo Muzio, L., et al. 2004. Histol Histopathol. 19: 119-28. PMID: 14702179
- Expression and prognostic examination of heat shock proteins (HSP 27, HSP 70, and HSP 90) in medulloblastoma. | Hauser, P., et al. 2006. J Pediatr Hematol Oncol. 28: 461-6. PMID: 16825994
- Anti-heat shock protein-27 (Hsp-27) antibody levels in patients with chest pain: association with established cardiovascular risk factors. | Shams, S., et al. 2008. Clin Chim Acta. 395: 42-6. PMID: 18501705
- Hsp-27 expression at diagnosis predicts poor clinical outcome in prostate cancer independent of ETS-gene rearrangement. | Foster, CS., et al. 2009. Br J Cancer. 101: 1137-44. PMID: 19707199
- Hsp-27 expression in invasive ductal breast carcinoma. | Grzegrzolka, J., et al. 2012. Folia Histochem Cytobiol. 50: 527-33. PMID: 23264215
- Heat shock proteins in the brain: role of Hsp70, Hsp 27, and HO-1 (Hsp32) and their therapeutic potential. | Sharp, FR., et al. 2013. Transl Stroke Res. 4: 685-92. PMID: 24323422
- Geranylgeranylacetone attenuates cerebral ischemia-reperfusion injury in rats through the augmentation of HSP 27 phosphorylation: a preliminary study. | Matsuo, K., et al. 2021. BMC Neurosci. 22: 9. PMID: 33557752
- Assessment of stress gene mRNAs (HSP-27, 60 and 70) in obstructed rabbit urinary bladder using a semi-quantitative RT-PCR method. | Zhao, Y., et al. 1995. Mol Cell Biochem. 148: 1-7. PMID: 7476928
- Distribution of Hsp-27 and HER-2/neu in in situ and invasive ductal breast carcinomas. | Storm, FK., et al. 1995. Ann Surg Oncol. 2: 43-8. PMID: 7530588
- Hsp-27 has no diagnostic or prognostic significance in prostate or bladder cancers. | Storm, FK., et al. 1993. Urology. 42: 379-82. PMID: 8212437
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSP 27 Antibody (G3.1) | sc-59562 | 100 µg/ml | $322.00 |