Date published: 2026-4-24

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HSP 27 Inhibitors

Heat shock proteins (HSPs) are a family of proteins that are produced by cells in response to various stressors, including heat shock, oxidative stress, and toxic chemicals. Among the HSPs, HSP 27, also known as HSPB1, stands out due to its distinct characteristics and functions. This small molecular weight protein plays a crucial role in assisting protein refolding, preventing protein aggregation, and modulating cytoskeletal dynamics. Additionally, HSP 27 has been implicated in cellular processes such as cell proliferation, differentiation, and survival. Its dynamic roles in various cellular mechanisms underscore its importance in maintaining cellular homeostasis under stress conditions. HSP 27 inhibitors are chemical entities designed to target and modulate the activity of HSP 27. The objective of these inhibitors is to interfere with the functions of HSP 27, altering its chaperone activity, its interactions with other proteins, or its involvement in cellular signaling pathways. The intricate regulatory mechanisms of HSP 27, governed by processes such as phosphorylation, make it an attractive target for the development of specific inhibitors.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

CID 755673

521937-07-5sc-205246
10 mg
$203.00
1
(1)

CID 755673 is a selective modulator of heat shock protein 27 (Hsp27), exhibiting unique binding affinity that enhances its chaperone activity. This compound engages in specific molecular interactions that stabilize client proteins under stress conditions, promoting cellular resilience. Its distinct pathway influences the phosphorylation state of Hsp27, thereby modulating downstream signaling cascades. The compound's kinetic profile reveals a rapid onset of action, contributing to its effectiveness in cellular stress responses.

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$153.00
$396.00
113
(4)

A potent kinase inhibitor, staurosporine can reduce the expression of HSP 27, affecting stress responses.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

This PI3K inhibitor may reduce HSP 27 levels, thereby modulating cellular responses to stress.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

Inhibition of p38 MAPK by SB203580 can lead to decreased HSP 27 expression.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

This MEK inhibitor might lead to reduced HSP 27 levels, affecting stress response pathways.

2-Deoxy-D-glucose

154-17-6sc-202010
sc-202010A
1 g
5 g
$70.00
$215.00
26
(2)

This glucose analog can reduce HSP 27 expression, altering cellular stress responses.

Heat Shock Protein Inhibitor I

218924-25-5sc-221709
5 mg
$97.00
5
(1)

A heat shock protein synthesis inhibitor that can specifically reduce HSP 27 levels.

Stat3 Inhibitor III, WP1066

857064-38-1sc-203282
10 mg
$132.00
72
(1)

As a STAT3 inhibitor, this agent may down-regulate HSP 27 expression in certain contexts.

Geldanamycin

30562-34-6sc-200617B
sc-200617C
sc-200617
sc-200617A
100 µg
500 µg
1 mg
5 mg
$39.00
$59.00
$104.00
$206.00
8
(1)

This Hsp90 inhibitor can indirectly lead to reduced HSP 27 levels by affecting its stability.

Triptolide

38748-32-2sc-200122
sc-200122A
1 mg
5 mg
$90.00
$204.00
13
(1)

Triptolide can decrease HSP 27 expression, contributing to its broad cellular effects.