HSP 27 Activators
HSP27 activators constitute a diverse array of compounds that modulate the activity of Heat Shock Protein 27 (HSP27), a molecular chaperone involved in cellular protection and stress response. Among the selected chemicals, Geldanamycin, Quercetin, 17-AAG (Tanespimycin), Celastrol, Epigallocatechin Gallate (EGCG), KNK437, SB203580, Withaferin A, SB216763, Celastrol (Tripterine), Methotrexate, and Pifithrin-μ have been identified as activators of HSP27. These activators exert their effects through both direct and indirect mechanisms. Geldanamycin and 17-AAG indirectly activate HSP27 by inhibiting HSP90, leading to the release of HSP27 from the HSP90 complex and allowing it to exert its chaperone functions. Quercetin, Celastrol, and EGCG, on the other hand, indirectly activate HSP27 by modulating the MAPK signaling pathway, specifically influencing the p38 MAPK pathway, resulting in the phosphorylation and activation of HSP27.
KNK437 indirectly activates HSP27 by inhibiting HSP70, leading to the upregulation and activation of HSP27, contributing to the cellular stress response. SB203580, a p38 MAPK inhibitor, prevents the phosphorylation and inactivation of HSP27, allowing it to remain active and enhance cellular protection. Withaferin A and Celastrol, through their impact on the MAPK pathway, contribute to the phosphorylation and activation of HSP27. SB216763, a GSK-3β inhibitor, indirectly activates HSP27 by preventing its phosphorylation and degradation. Methotrexate influences the NF-κB signaling pathway, leading to the upregulation of HSP27 expression, enhancing the cellular stress response. Pifithrin-μ indirectly activates HSP27 by inhibiting p53, allowing for increased levels of HSP27 expression and contributing to the cellular stress response.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin indirectly activates HSP27 by modulating the MAPK signaling pathway. It influences the p38 MAPK pathway, leading to phosphorylation and activation of HSP27. This activated HSP27 then plays a role in cellular protection and stress response. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG is an HSP90 inhibitor that indirectly activates HSP27 by disrupting the HSP90 chaperone complex. Upon HSP90 inhibition, HSP27 is released and becomes active, contributing to cellular protection and stress response. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol indirectly activates HSP27 by modulating the MAPK signaling pathway. It influences the p38 MAPK pathway, leading to phosphorylation and activation of HSP27. This activated HSP27 then plays a role in cellular protection and stress response. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG indirectly activates HSP27 by modulating the MAPK signaling pathway. It influences the p38 MAPK pathway, leading to phosphorylation and activation of HSP27. This activated HSP27 then plays a role in cellular protection and stress response. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A indirectly activates HSP27 by modulating the MAPK signaling pathway. It influences the p38 MAPK pathway, leading to phosphorylation and activation of HSP27. This activated HSP27 then plays a role in cellular protection and stress response. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB216763 is a GSK-3β inhibitor that indirectly activates HSP27 by preventing its phosphorylation and degradation. By inhibiting GSK-3β, SB216763 promotes the stabilization and activation of HSP27, contributing to cellular protection and stress response. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate indirectly activates HSP27 by influencing the NF-κB signaling pathway. It modulates the activity of NF-κB, leading to the upregulation of HSP27 expression. This increased expression enhances the cellular stress response and chaperone functions of HSP27. | ||||||
Pifithrin-μ | 64984-31-2 | sc-203195 sc-203195A | 10 mg 50 mg | $130.00 $379.00 | 4 | |
Pifithrin-μ indirectly activates HSP27 by inhibiting p53. By preventing the inhibitory effects of p53 on HSP27 expression, Pifithrin-μ allows for increased levels of HSP27, contributing to the cellular stress response and chaperone functions of HSP27. | ||||||