NUDT21 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
Leptomycin B inhibits CRM1, preventing the nuclear export of NUDT21. Retention of NUDT21 in the nucleus disrupts its interaction with target mRNAs, resulting in inhibition of mRNA processing and gene expression. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
C646 inhibits p300 histone acetyltransferase, affecting chromatin structure. The modified chromatin environment impedes the recruitment of NUDT21 to target genes, resulting in inhibition of mRNA processing and gene expression. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
Flavopiridol, a CDK inhibitor, disrupts the phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II. This interference hinders NUDT21 recruitment to actively transcribing genes, leading to impaired mRNA processing and reduced gene expression. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
Pladienolide B interferes with spliceosome assembly, affecting pre-mRNA splicing. The altered splicing patterns disrupt NUDT21-mediated mRNA processing, leading to reduced gene expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D intercalates into DNA, inhibiting transcription. The impaired transcription process prevents NUDT21 access to nascent transcripts, resulting in inhibition of mRNA processing and gene expression. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Fluorouracil disrupts thymidylate synthesis, affecting nucleotide availability. The altered nucleotide pool hampers NUDT21-mediated mRNA processing, leading to decreased gene expression. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $126.00 | 5 | |
Chaetocin inhibits histone methyltransferase SUV39H1, altering chromatin methylation. The modified chromatin environment impairs NUDT21 recruitment to target genes, resulting in inhibition of mRNA processing and reduced gene expression. | ||||||
Actinomycin V | 18865-48-0 | sc-507379 | 1 mg | $450.00 | ||
Actinomycin V, similar to Actinomycin D, intercalates into DNA, inhibiting transcription. The disrupted transcription process prevents NUDT21 access to nascent transcripts, resulting in inhibition of mRNA processing and gene expression. | ||||||
6-Azauracil | 461-89-2 | sc-207092 | 5 g | $59.00 | ||
6-Azauracil inhibits inosine monophosphate dehydrogenase, affecting nucleotide metabolism. The altered nucleotide pool hampers NUDT21-mediated mRNA processing, leading to decreased gene expression. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $145.00 $569.00 | 4 | |
Ellipticine intercalates into DNA, inducing DNA damage. The DNA lesions interfere with transcription, preventing NUDT21 access to nascent transcripts and resulting in inhibition of mRNA processing and gene expression. | ||||||