HSF1 Antibody (C-5): sc-17756
- HSF1 Antibody (C-5) is a mouse monoclonal IgG2b κ, cited in 11 publications, provided at 200 µg/ml
- raised against amino acids 219-529 of HSF1 of human origin
- recommended for detection of HSF1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- TransCruz reagent for Gel Supershift and ChIP applications (sc-17756 X, 200 µg/0.1 ml)
- See HSF1 (E-4): sc-17757 for HSF1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP is the preferred secondary detection reagent for HSF1 Antibody (C-5) for WB and IHC(P) applications. This reagent is now offered in a bundle with HSF1 Antibody (C-5) (see ordering information below).
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HSF1 Antibody (C-5) is a mouse monoclonal IgG2b antibody that detects heat shock factor 1 (HSF1) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry (IHC), and enzyme-linked immunosorbent assay (ELISA). HSF1 plays a crucial role in the cellular response to stress by regulating the expression of heat shock proteins, which are essential for protein folding and protection against aggregation during stressful conditions. This function is particularly important as HSF1 helps maintain cellular homeostasis and prevents damage that could lead to diseases such as neurodegeneration and cancer. Under normal conditions, HSF1 exists as a monomer, but upon activation due to stress, HSF1 forms trimers that translocate to the nucleus, where HSF1 binds to heat shock elements in the promoter regions of target genes, thereby initiating their transcription. The regulation of HSF1 is influenced by post-translational modifications, such as phosphorylation, which can modulate activity and stability, highlighting the intricate control mechanisms that govern stress responses in cells. HSF1 monoclonal antibody (C-5) is an invaluable tool for researchers studying the heat shock response and its implications in various biological processes and diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSF1 Antibody (C-5) | sc-17756 | 200 µg/ml | $322.00 | |||
HSF1 Antibody (C-5): m-IgG2b BP-HRP Bundle | sc-551923 | 200 µg Ab; 10 µg BP | $361.00 | |||
HSF1 Antibody (C-5) X | sc-17756 X | 200 µg/0.1 ml | $322.00 |